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Balinatunfib

Name: Balinatunfib
Brand: TargetMol
SKU: T89932
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T89932Cas No. 2248726-53-4

Alias TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566

Balinatunfib (SAR-441566) is an orally active and highly selective inhibitor of TNFR1 signaling that exerts its mechanism of action by binding to the central pocket of the soluble TNFα (sTNFα) trimer, stabilizing an asymmetric and inactive conformation that selectively blocks interaction with TNFR1 without affecting TNFR2, Balinatunfib suppresses downstream proinflammatory signaling cascades and demonstrating robust anti-inflammatory activity suitable for mechanistic and translational research in autoimmune and inflammatory diseases.

Balinatunfib

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Purity: 99.20%

Catalog No. T89932Alias TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566Cas No. 2248726-53-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	-	In Stock
5 mg	$263	-	In Stock
10 mg	$428	-	In Stock
25 mg	$485	-	In Stock
1 mL x 10 mM (in DMSO)	$292	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.20%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Balinatunfib (SAR-441566) is an orally active and highly selective inhibitor of TNFR1 signaling that exerts its mechanism of action by binding to the central pocket of the soluble TNFα (sTNFα) trimer, stabilizing an asymmetric and inactive conformation that selectively blocks interaction with TNFR1 without affecting TNFR2, Balinatunfib suppresses downstream proinflammatory signaling cascades and demonstrating robust anti-inflammatory activity suitable for mechanistic and translational research in autoimmune and inflammatory diseases.
In vivo	In the collagen-induced arthritis (CIA) rat model, oral administration of Balinatunfib resulted in dose-dependent reductions in paw swelling and inflammation. Furthermore, histological analysis indicated that the treatment reduced bone erosion and cartilage destruction scores in the affected joints [2].
Synonyms	TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566

Chemical Properties

Molecular Weight	502.52
Formula	C₂₇H₂₄F₂N₆O₂
Cas No.	2248726-53-4
Smiles	O(C(F)F)C1=C2[C@@]3(N4C([C@@](C3)(N(C)C(=O)C2=CC=C1)[H])=NC=5C4=CC(=CC5)C=6C=NC(=NC6)C7(N)CCC7)[H]
Color	Orange
Appearance	Solid

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (179.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9900 mL	9.9499 mL	19.8997 mL	99.4985 mL
5 mM	0.3980 mL	1.9900 mL	3.9799 mL	19.8997 mL
10 mM	0.1990 mL	0.9950 mL	1.9900 mL	9.9499 mL
20 mM	0.0995 mL	0.4975 mL	0.9950 mL	4.9749 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9900 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc