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Balinatunfib

Name: Balinatunfib
Brand: TargetMol
SKU: T89932
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T89932Cas No. 2248726-53-4

Alias TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566

Balinatunfib (SAR-441566) is an orally active and highly selective inhibitor of TNFR1 signaling that exerts its mechanism of action by binding to the central pocket of the soluble TNFα (sTNFα) trimer, stabilizing an asymmetric and inactive conformation that selectively blocks interaction with TNFR1 without affecting TNFR2, Balinatunfib suppresses downstream proinflammatory signaling cascades and demonstrating robust anti-inflammatory activity suitable for mechanistic and translational research in autoimmune and inflammatory diseases.

Balinatunfib

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Purity: 99.20%

Catalog No. T89932Alias TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566Cas No. 2248726-53-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	-	In Stock
5 mg	$263	-	In Stock
10 mg	$428	-	In Stock
25 mg	$485	-	In Stock
1 mL x 10 mM (in DMSO)	$292	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.20%

Appearance:Solid

Color:Orange

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Balinatunfib (SAR-441566) is an orally active and highly selective inhibitor of TNFR1 signaling that exerts its mechanism of action by binding to the central pocket of the soluble TNFα (sTNFα) trimer, stabilizing an asymmetric and inactive conformation that selectively blocks interaction with TNFR1 without affecting TNFR2, Balinatunfib suppresses downstream proinflammatory signaling cascades and demonstrating robust anti-inflammatory activity suitable for mechanistic and translational research in autoimmune and inflammatory diseases.
In vivo	In the collagen-induced arthritis (CIA) rat model, oral administration of Balinatunfib resulted in dose-dependent reductions in paw swelling and inflammation. Furthermore, histological analysis indicated that the treatment reduced bone erosion and cartilage destruction scores in the affected joints [2].
Synonyms	TNFα activity modulator 3, SAR-441566, SAR441566, SAR 441566

Chemical Properties

Molecular Weight	502.52
Formula	C₂₇H₂₄F₂N₆O₂
Cas No.	2248726-53-4
Smiles	O(C(F)F)C1=C2[C@@]3(N4C([C@@](C3)(N(C)C(=O)C2=CC=C1)[H])=NC=5C4=CC(=CC5)C=6C=NC(=NC6)C7(N)CCC7)[H]

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (179.1 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9900 mL	9.9499 mL	19.8997 mL	99.4985 mL
5 mM	0.3980 mL	1.9900 mL	3.9799 mL	19.8997 mL
10 mM	0.1990 mL	0.9950 mL	1.9900 mL	9.9499 mL
20 mM	0.0995 mL	0.4975 mL	0.9950 mL	4.9749 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9900 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc