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Anti-L-selectin Antibody-APC (4Y137)
🥰Excellent
Catalog No. TMAY-02084A
Anti-L-selectin Antibody-APC (4Y137) is a APC-conjugated Mouse antibody targeting L-selectin. Anti-L-selectin Antibody-APC (4Y137) can be used in FCM.
Anti-L-selectin Antibody-APC (4Y137)
Anti-L-selectin Antibody-APC (4Y137)
🥰Excellent
Catalog No. TMAY-02084A
Anti-L-selectin Antibody-APC (4Y137) is a APC-conjugated Mouse antibody targeting L-selectin. Anti-L-selectin Antibody-APC (4Y137) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-L-selectin Antibody-APC (4Y137) is a APC-conjugated Mouse antibody targeting L-selectin. Anti-L-selectin Antibody-APC (4Y137) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4Y137 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human SELL(CD62L) expression on human whole blood lymphocytes. Cells were stained with APC-conjugated anti-Human SELL(CD62L). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 10 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD62L / L-Selectin (rh CD62L / L-Selectin; TMPY-02024; P14151-1; Met1-Asn332) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| Conjucates | APC |
| Others Formats | Unconjugated/PerCP/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD62L / L-Selectin Protein (TMPY-02024) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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