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Tamarixetin

Name: Tamarixetin
Brand: TargetMol
SKU: TN1039
Price: 83 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: 4'-O-Methyl Quercetin) Copy Product Info

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Synonyms: 4'-O-Methyl Quercetin

Catalog No. TN1039 Copy Product Info

Purity: 99.21%

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Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin exhibiting multi-target biological activities including anti-inflammatory, antioxidant, antitumor, neuroprotective, and cardiovascular protective effects. Tamarixetin exerts its biological activity through multiple mechanisms such as direct radical scavenging, signaling pathway regulation, enzyme inhibition, and receptor binding.

Cas No. 603-61-2

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Pack Size	Price	USA Stock	Global Stock
1 mg	$83	In Stock	In Stock
5 mg	$197	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$489	In Stock	In Stock
50 mg	$713	In Stock	In Stock
100 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$238	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.21%

Color:Yellow

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin exhibiting multi-target biological activities including anti-inflammatory, antioxidant, antitumor, neuroprotective, and cardiovascular protective effects. Tamarixetin exerts its biological activity through multiple mechanisms such as direct radical scavenging, signaling pathway regulation, enzyme inhibition, and receptor binding.
Targets & IC50	CYP2C:1.4 μM, HCC44 cells:20.3 μM, Caco-2 cells:82 μM, Molt-3 cells:7.5 μM, K562 cells:24 μM, A549 cells:19.6 μM, HL-60 cells:7.5 μM, U-937 cells:5.5 μM
In vitro	Methods: Add tamarixetin at concentration gradients (0, 50, 100, 150 μM) to CRC cells (HT-29, HCT-116), treat for 24 hours, and assess cell viability and proliferation using the MTT assay and EdU assay. Results: Tamarixetin dose-dependently inhibited CRC cell proliferation and significantly suppressed DNA synthesis. [1] Methods: BMDCs derived from mouse bone marrow were stimulated with LPS (100 ng/mL). Tamarixetin (50 μM) was added at different time points (0–120 min) post-LPS stimulation. Supernatants were collected and cytokines were detected by ELISA. Results: Tamarixetin significantly suppressed proinflammatory cytokine secretion (IL-6, TNF-α, IL-12p70) and markedly increased anti-inflammatory cytokine IL-10 secretion. [2]
In vivo	Methods: HCT-116 or HT-29 cells (1×10⁶) were subcutaneously implanted into 4-week-old nude mice. Four days post-implantation, mice were randomly assigned to treatment groups and administered Tamarixetin (25 mg/kg) via intraperitoneal injection every other day for 14 days. Results: Tamarixetin significantly inhibited tumor growth in vivo. [1] Methods: C57BL/6 mice were administered LPS (25 mg/kg) intraperitoneally to induce endotoxin shock. The experimental group received Tamarixetin (1 mg/kg) intraperitoneally one hour prior to LPS injection as pretreatment. The control group received the solvent. Results: The survival rate of mice in the Tamarixetin pretreatment group increased to approximately 80%, while all mice in the control group died. [2]
Synonyms	4'-O-Methyl Quercetin

Chemical Properties

Molecular Weight	316.26
Formula	C₁₆H₁₂O₇
Cas No.	603-61-2
Smiles	COc1ccc(cc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
Relative Density.	1.634 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.4 mg/mL (13.91 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1620 mL	15.8098 mL	31.6196 mL	158.0978 mL
5 mM	0.6324 mL	3.1620 mL	6.3239 mL	31.6196 mL
10 mM	0.3162 mL	1.5810 mL	3.1620 mL	15.8098 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.