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SARS-CoV-2 nsp13-IN-1

Name: SARS-CoV-2 nsp13-IN-1
Brand: TargetMol
SKU: T62413
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T62413Cas No. 1005304-44-8

SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.

SARS-CoV-2 nsp13-IN-1

🥰Excellent

Purity: 99.44%

Catalog No. T62413Cas No. 1005304-44-8

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	-	In Stock
5 mg	$53	-	In Stock
10 mg	$88	-	In Stock
25 mg	$148	-	In Stock
50 mg	$219	-	In Stock
100 mg	$325	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.44%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SARS-CoV-2 nsp13-IN-1 (compound C1) is a potent inhibitor of nsp13 (non-structural protein 13), selectively inhibiting nsp13 ssDNA+ATPase with an IC50 of 6 μM, but not ssDNA-ATPase, and can be used to study COVID-19.
Targets&IC50	ATPase:6±0.5 μM

Chemical Properties

Molecular Weight	432.47
Formula	C₂₇H₂₀N₄O₂
Cas No.	1005304-44-8
Smiles	CC1=NC2=C(C=CC=N2)C(=O)N1C1=CC=C(NC(=O)C2=CC=C(C=C2)C2=CC=CC=C2)C=C1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 30 mg/mL (69.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3123 mL	11.5615 mL	23.1230 mL	115.6150 mL
5 mM	0.4625 mL	2.3123 mL	4.6246 mL	23.1230 mL
10 mM	0.2312 mL	1.1561 mL	2.3123 mL	11.5615 mL
20 mM	0.1156 mL	0.5781 mL	1.1561 mL	5.7807 mL
50 mM	0.0462 mL	0.2312 mL	0.4625 mL	2.3123 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc