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Anti-PDGF-D/SCDGFB Polyclonal Antibody
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Catalog No. TMAB-10123
Anti-PDGF-D/SCDGFB Polyclonal Antibody is a Rabbit antibody targeting PDGF-D/SCDGFB. Anti-PDGF-D/SCDGFB Polyclonal Antibody can be used in WB.
Anti-PDGF-D/SCDGFB Polyclonal Antibody
Anti-PDGF-D/SCDGFB Polyclonal Antibody
😃Good
Catalog No. TMAB-10123
Anti-PDGF-D/SCDGFB Polyclonal Antibody is a Rabbit antibody targeting PDGF-D/SCDGFB. Anti-PDGF-D/SCDGFB Polyclonal Antibody can be used in WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-PDGF-D/SCDGFB Polyclonal Antibody is a Rabbit antibody targeting PDGF-D/SCDGFB. Anti-PDGF-D/SCDGFB Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Rabbit,Sheep) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Secreted. Note=Released by platelets upon wounding. |
| Tissue Specificity | Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | SCDGFB (Spinal cord derived growth factor B) is a member of the platelet derived growth factor family. It only forms homodimers and does not dimerize with the other three family members. It is a potent mitogen for cells of mesenchymal origin. It is activated by proteolytic cleavage and this active form acts as a specific ligand for beta platelet derived growth factor receptor. It is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound. It induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. |
| Immunogen | KLH conjugated synthetic peptide: human SCDGFB |
| Antigen Species | Human |
| Gene Name | PDGFD |
| Gene ID | |
| Protein Name | Platelet-derived growth factor D |
| Uniprot ID | |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). |
| Molecular Weight | Theoretical: 14/41 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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