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FDI-6

Name: FDI-6
Brand: TargetMol
SKU: T4005
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4005Cas No. 313380-27-7

Alias FDI6, FDI 6

FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6(FDI6) binds to the FOXM1 protein and specifically downregulates FOXM1-activated genes.

FDI-6

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Purity: 99.94%

Catalog No. T4005Alias FDI6, FDI 6Cas No. 313380-27-7

FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6(FDI6) binds to the FOXM1 protein and specifically downregulates FOXM1-activated genes.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$123	In Stock	In Stock
25 mg	$213	In Stock	In Stock
50 mg	$305	In Stock	In Stock
100 mg	$453	In Stock	In Stock
200 mg	$663	-	In Stock
1 mL x 10 mM (in DMSO)	$80	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.94%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	FDI-6 is an effective and selective inhibitor of FOXM1 that blocks DNA binding. FDI-6(FDI6) binds to the FOXM1 protein and specifically downregulates FOXM1-activated genes.
In vitro	FDI-6 specifically downregulates FOXM1-activated genes with FOXM1 occupancy confirmed by ChIP-PCR. This small molecule-mediated effect is selective for FOXM1-controlled genes with no effect on genes regulated by homologous forkhead family factors.
Synonyms	FDI6, FDI 6

Chemical Properties

Molecular Weight	437.43
Formula	C₁₉H₁₁F₄N₃OS₂
Cas No.	313380-27-7
Smiles	Nc1c(sc2nc(cc(c12)C(F)(F)F)-c1cccs1)C(=O)Nc1ccc(F)cc1
Relative Density.	1.562 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (114.3 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (5.72 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2861 mL	11.4304 mL	22.8608 mL	114.3040 mL
5 mM	0.4572 mL	2.2861 mL	4.5722 mL	22.8608 mL
10 mM	0.2286 mL	1.1430 mL	2.2861 mL	11.4304 mL
20 mM	0.1143 mL	0.5715 mL	1.1430 mL	5.7152 mL
50 mM	0.0457 mL	0.2286 mL	0.4572 mL	2.2861 mL
100 mM	0.0229 mL	0.1143 mL	0.2286 mL	1.1430 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc