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Anti-L1CAM Antibody-PE (4G234)
🥰Excellent
Catalog No. TMAY-00336P
Anti-L1CAM Antibody-PE (4G234) is a PE-conjugated Rabbit antibody targeting L1CAM. Anti-L1CAM Antibody-PE (4G234) can be used in FCM.
Anti-L1CAM Antibody-PE (4G234)
Anti-L1CAM Antibody-PE (4G234)
🥰Excellent
Catalog No. TMAY-00336P
Anti-L1CAM Antibody-PE (4G234) is a PE-conjugated Rabbit antibody targeting L1CAM. Anti-L1CAM Antibody-PE (4G234) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-L1CAM Antibody-PE (4G234) is a PE-conjugated Rabbit antibody targeting L1CAM. Anti-L1CAM Antibody-PE (4G234) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4G234 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD171 expression in HeLa cells. |
| Application | FCM |
| Recommended Dose | 1 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD171 / N-CAML1 / L1CAM (rh CD171 / N-CAML1 / L1CAM; TMPY-01431; NP_000416.1; Met 1-Glu 1120) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | L1 cell adhesion molecule (L1CAM), also designated as CD171, is a cell adhesion receptor of the immunoglobulin superfamily, known for its roles in nerve cell function. While originally believed to be present only in brain cells, in recent years L1-CAM has been detected in other tissues, and a variety of cancer cells, including some common types of human cancer. L1CAM interacts with a variety of ligands including axonin-1, CD9, neurocan, and integrins, and it has been revealed that the RGD motif in the sixth Ig domain of L1CAM is a binding site for integrins, thus important for nuclear signaling. Disruption of L1CAM function causes three X-linked neurological syndromes, i.e. hydrocephalus, MASA syndrome (mental retardation, aphasia, shuffling gait, and adducted thumbs), and spastic paraplegia syndrome. Overexpression of L1CAM in normal and cancer cells increased motility, enhanced growth rate, and promoted cell transformation and tumorigenicity. Recent work has identified L1CAM (CD171) as a novel marker for human carcinoma progression, and a candidate for anti-cancer therapy. |
| Conjucates | PE |
| Others Formats | Unconjugated/FITC/HRP |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Human CD171 protein (TMPY-01431) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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