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MG-115

Name: MG-115
Brand: TargetMol
SKU: T21617
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21617Cas No. 133407-86-0

Alias Z-LL-Nva-CHO

MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].

MG-115

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Purity: 97.10%

Catalog No. T21617Alias Z-LL-Nva-CHOCas No. 133407-86-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$44	-	In Stock
5 mg	$98	-	In Stock
10 mg	$179	-	In Stock
25 mg	$328	-	In Stock
50 mg	$488	-	In Stock
100 mg	$713	-	In Stock
200 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.10%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
In vitro	MG-115, at concentrations ranging from 0.1 to 10 μM over 24 hours, not only diminishes the viability of HepG2 cells in a dose-dependent manner but also enhances the reporter gene expression driven by CWK 18 DNA condensates. Cell viability assays further confirm that MG-115's exposure leads to a dose-dependent decrease in cell viability, quantitatively inhibiting proteasomal activity with an IC 50 value of 2 μM in HepG2 cells.
Synonyms	Z-LL-Nva-CHO

Chemical Properties

Molecular Weight	461.59
Formula	C₂₅H₃₉N₃O₅
Cas No.	133407-86-0
Smiles	CCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O
Relative Density.	1.082 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (97.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 4 mg/mL (8.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1664 mL	10.8321 mL	21.6642 mL	108.3212 mL
5 mM	0.4333 mL	2.1664 mL	4.3328 mL	21.6642 mL
10 mM	0.2166 mL	1.0832 mL	2.1664 mL	10.8321 mL
20 mM	0.1083 mL	0.5416 mL	1.0832 mL	5.4161 mL
50 mM	0.0433 mL	0.2166 mL	0.4333 mL	2.1664 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc