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MG-115

Catalog No. T21617 CAS 133407-86-0

Synonyms: Z-LL-Nva-CHO

MG-115 is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].

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MG-115, CAS 133407-86-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

In vitro

MG-115 (0.1-10 μM; 24 h) decreases the viability of HepG2 cells in a dose-dependent manner [3]. MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK 18 DNA condensates [3]. Cell Viability Assay [3] Cell Line: HepG2 cells Concentration: 0.1, 1, 2, 5, 10 μM Incubation Time: 24 hours Result: Dose-dependently decreased cell viability. Inhibited the proteasomal activity, with an IC 50 of 2 μM.

Synonyms	Z-LL-Nva-CHO
Molecular Weight	461.59
Formula	C25H39N3O5
CAS No.	133407-86-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 45mg/mL (97.5mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Rock KL, et, al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9;78(5):761-71. 2. Lopes UG, et, al. p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem. 1997 May 16;272(20):12893-6. 3. Kim J, et, al. The proteasome metabolizes peptide-mediated nonviral gene delivery systems. Gene Ther. 2005 Nov;12(21):1581-90.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MG-115 133407-86-0 Proteases/Proteasome Ubiquitination Proteasome Z-LL-Nva-CHO Inhibitor inhibitor inhibit

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