Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 222.00 | |
10 mg | In stock | $ 355.00 | |
25 mg | In stock | $ 468.00 | |
50 mg | In stock | $ 572.00 | |
100 mg | In stock | $ 913.00 |
Description | MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3]. |
In vitro | MG-115, at concentrations ranging from 0.1 to 10 μM over 24 hours, not only diminishes the viability of HepG2 cells in a dose-dependent manner but also enhances the reporter gene expression driven by CWK 18 DNA condensates. Cell viability assays further confirm that MG-115's exposure leads to a dose-dependent decrease in cell viability, quantitatively inhibiting proteasomal activity with an IC 50 value of 2 μM in HepG2 cells. |
Synonyms | Z-LL-Nva-CHO |
Molecular Weight | 461.59 |
Formula | C25H39N3O5 |
CAS No. | 133407-86-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45mg/mL (97.5mM)
You can also refer to dose conversion for different animals. More
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MG-115 133407-86-0 Proteases/Proteasome Ubiquitination Proteasome MG115 MG 115 Z-LL-Nva-CHO inhibitor inhibit