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MG-115

Name: MG-115
Brand: TargetMol
SKU: T21617
Rating: 4.5 (1 reviews)

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Catalog No. T21617Cas No. 133407-86-0

Alias Z-LL-Nva-CHO

MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].

MG-115

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Catalog No. T21617Alias Z-LL-Nva-CHOCas No. 133407-86-0

Pack Size	Price	Availability
1 mg	$44	6-8 weeks
5 mg	$98	6-8 weeks
10 mg	$179	6-8 weeks
25 mg	$328	6-8 weeks
50 mg	$488	6-8 weeks
100 mg	$713	6-8 weeks
200 mg	$987	6-8 weeks

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Product Introduction

Bioactivity

Description	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
In vitro	MG-115, at concentrations ranging from 0.1 to 10 μM over 24 hours, not only diminishes the viability of HepG2 cells in a dose-dependent manner but also enhances the reporter gene expression driven by CWK 18 DNA condensates. Cell viability assays further confirm that MG-115's exposure leads to a dose-dependent decrease in cell viability, quantitatively inhibiting proteasomal activity with an IC 50 value of 2 μM in HepG2 cells.
Synonyms	Z-LL-Nva-CHO

Chemical Properties

Molecular Weight	461.59
Formula	C₂₅H₃₉N₃O₅
Cas No.	133407-86-0
Smiles	CCCC(NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C=O
Relative Density.	1.082 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (97.49 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1664 mL	10.8321 mL	21.6642 mL	108.3212 mL
5 mM	0.4333 mL	2.1664 mL	4.3328 mL	21.6642 mL
10 mM	0.2166 mL	1.0832 mL	2.1664 mL	10.8321 mL
20 mM	0.1083 mL	0.5416 mL	1.0832 mL	5.4161 mL
50 mM	0.0433 mL	0.2166 mL	0.4333 mL	2.1664 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc