Powder: -20°C for 3 years
In solvent: -80°C for 2 years
MG-115 is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3].
Description | MG-115 is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteasome, induces p53-dependent apoptosis [1] [2] [3]. |
In vitro | MG-115 (0.1-10 μM; 24 h) decreases the viability of HepG2 cells in a dose-dependent manner [3]. MG-115 (0.1-10 μM; 24 h) amplifies the reporter gene expression mediated by CWK 18 DNA condensates [3]. Cell Viability Assay [3] Cell Line: HepG2 cells Concentration: 0.1, 1, 2, 5, 10 μM Incubation Time: 24 hours Result: Dose-dependently decreased cell viability. Inhibited the proteasomal activity, with an IC 50 of 2 μM. |
Synonyms | Z-LL-Nva-CHO |
Molecular Weight | 461.59 |
Formula | C25H39N3O5 |
CAS No. | 133407-86-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 45mg/mL (97.5mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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MG-115 133407-86-0 Proteases/Proteasome Ubiquitination Proteasome Z-LL-Nva-CHO Inhibitor inhibitor inhibit