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Anti-PELP1 Antibody (2N527)
(Synonyms: Transcription factor HMX3, Proline-, glutamic acid- and leucine-rich protein 1, PELP 1, Modulator of non-genomic activity of estrogen receptor, HMX3 MNAR) Copy Product Info
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Synonyms: Transcription factor HMX3, Proline-, glutamic acid- and leucine-rich protein 1, PELP 1, Modulator of non-genomic activity of estrogen receptor, HMX3 MNAR
Catalog No. TMAH-00876 Copy Product Info
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Anti-PELP1 Antibody (2N527) is an antibody targeting PELP1. Anti-PELP1 Antibody (2N527) can be used in ELISA,IHC,WB.
Anti-PELP1 Antibody
(2N527)
(2N527)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $209 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
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| Description | Anti-PELP1 Antibody (2N527) is an antibody targeting PELP1. Anti-PELP1 Antibody (2N527) can be used in ELISA,IHC,WB. |
| Synonyms | Transcription factor HMX3, Proline-, glutamic acid- and leucine-rich protein 1, PELP 1, Modulator of non-genomic activity of estrogen receptor, HMX3 MNAR |
| Ig Type | Rabbit IgG |
| Clone | 2N527 |
| Reactivity | Human |
| Application | |
| Recommended Dose | WB:1:500-1:5000; IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Cytoplasm. |
| Tissue Specificity | Widely expressed. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors. Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1. May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human PELP1 |
| Antigen Species | Human |
| Gene Name | PELP1 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Epigenetics and Nuclear Signaling, Signal transduction |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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