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Rhapontigenin

Name: Rhapontigenin
Brand: TargetMol
SKU: T3776
Price: 51 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3776Cas No. 500-65-2

Alias Protigenin

Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).

Rhapontigenin

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Purity: 99.88%

Catalog No. T3776Alias ProtigeninCas No. 500-65-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$51	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$184	In Stock	In Stock
25 mg	$357	In Stock	In Stock
50 mg	$537	In Stock	In Stock
100 mg	$672	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Color:White to Yellow

Resource Download

COA HPLC HNMR

Product Introduction

Rhapontigenin AI Summary

Rhapontigenin exhibits diverse bioactivity across multiple biological assays. It shows potent inhibitory effects on the proliferation of HL60 cells with an IC50 of 48000.0 nM and requires concentrations greater than 200000.0 nM to induce apoptosis in these cells. In mouse peritoneal macrophages activated by LPS, the compound inhibits nitric oxide production with an IC50 of 48000.0 nM. Additionally, it reduces nitric oxide, IL6, and MCP1 production in mouse J774 cells with IC50 values of 102800.0 nM, 99100.0 nM, and 19400.0 nM, respectively. In human MDA-MB-231 cells, it inhibits PI3K-dependent Rac1 activation and demonstrates dose-dependent suppression of cell migration and invasion at concentrations of 10 uM, 25 uM, and 50 uM, with inhibition percentages ranging from 17.0% to 70.0%. The compound also exhibits antioxidant activity, effectively scavenging a variety of radical species, and shows estrogenic activity in HepG2 cells by modulating ER-mediated transcriptional activation at concentrations of 1 uM and 10 uM. Moreover, Rhapontigenin acts as an alpha-glucosidase inhibitor with IC50 and Ki values around 15400.0 nM, indicating its potential utility in metabolic disorders..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Rhapontigenin (Protigenin) is a mechanism-based, selective inactivator of cytochrome P450 1A1 (IC50: 400 nM), an aryl hydrocarbon hydroxylase which activates polycyclic aromatic hydrocarbons that act as procarcinogens. Rhapontigenin is a natural analog of resveratrol with antioxidant and anti-cancer activity. At higher concentrations, rhapontigenin inhibits the proliferation of HL-60R and HepG2 cancer cell lines (IC50: 48 μM).
Targets&IC50	HL-60R:48 μM, HepG2 cells:48 μM, CYP1A1:400 nM
Synonyms	Protigenin

Chemical Properties

Molecular Weight	258.27
Formula	C₁₅H₁₄O₄
Cas No.	500-65-2
Smiles	COc1ccc(\C=C\c2cc(O)cc(O)c2)cc1O
Relative Density.	1.345 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 131.25 mg/mL (508.19 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8719 mL	19.3596 mL	38.7192 mL	193.5958 mL
5 mM	0.7744 mL	3.8719 mL	7.7438 mL	38.7192 mL
10 mM	0.3872 mL	1.9360 mL	3.8719 mL	19.3596 mL
20 mM	0.1936 mL	0.9680 mL	1.9360 mL	9.6798 mL
50 mM	0.0774 mL	0.3872 mL	0.7744 mL	3.8719 mL
100 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc