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Anti-STUB1 Antibody (3E854)
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Catalog No. TMAY-02371
Alias STUB1, STIP1 Homology and U Box-Containing Protein 1, E3 Ubiquitin-Protein Ligase CHIP, CLL-Associated Antigen KW-8, CHIP, Carboxy Terminus of Hsp70-Interacting Protein, Antigen NY-CO-7
Anti-STUB1 Antibody (3E854) is a Rabbit antibody targeting STUB1. Anti-STUB1 Antibody (3E854) can be used in IHC-P.
Anti-STUB1 Antibody (3E854)
Anti-STUB1 Antibody (3E854)
😃Good
Catalog No. TMAY-02371Alias STUB1, STIP1 Homology and U Box-Containing Protein 1, E3 Ubiquitin-Protein Ligase CHIP, CLL-Associated Antigen KW-8, CHIP, Carboxy Terminus of Hsp70-Interacting Protein, Antigen NY-CO-7
Anti-STUB1 Antibody (3E854) is a Rabbit antibody targeting STUB1. Anti-STUB1 Antibody (3E854) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $270 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P Reactivity: Human |
| Alias | STUB1, STIP1 Homology and U Box-Containing Protein 1, E3 Ubiquitin-Protein Ligase CHIP, CLL-Associated Antigen KW-8, CHIP, Carboxy Terminus of Hsp70-Interacting Protein, Antigen NY-CO-7 |
| Ig Type | Rabbit IgG |
| Clone | 3E854 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human STUB1 in human skeletal muscle with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human STUB1 in human placenta with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human STUB1 in human pancreas with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human STUB1 isoform 1 (Q9UNE7-1; Met 1-Tyr 303). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CHIP, the protein encoded by STUB1, is a central component of cellular protein homeostasis and interacts with several key proteins involved in the pathogenesis of manifold neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. CHIP/STUB1 ubiquitin ligase is a negative co-chaperone for HSP90/HSC70, and its expression is reduced or lost in several cancers, including breast cancer. Pathogenic variants in STUB1 were initially described in autosomal recessive spinocerebellar ataxia type 16 and dominant cerebellar ataxia with cerebellar cognitive dysfunction (SCA48). Data indicated that STUB1 deficiency leads both to the intracellular accumulation of protein aggregates and to an increase in the secretion of small extracellular vesicles (sEVs), including exosomes. Secreted sEVs are enriched in ubiquitinated and/or undegraded proteins and protein oligomers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human STUB1 protein |
| Antigen Species | Human |
| Biology Area | Adaptor Proteins |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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