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Piroctone olamine (Synonyms: Piroctone ethanolamine)

Name: Piroctone olamine
Brand: TargetMol
SKU: T0721
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T0721 Copy Product Info

Purity: 99.89%

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Piroctone olamine (Piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Piroctone olamine

Copy Product Info

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Catalog No. T0721

Synonyms Piroctone ethanolamine

Piroctone olamine (Piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Cas No. 68890-66-4

Pack Size	Price	USA Stock	Global Stock
100 mg	$41	In Stock	In Stock
200 mg	$52	In Stock	In Stock
500 mg	$74	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Piroctone olamine AI Summary

Piroctone olamine demonstrates antiviral activity against SARS-CoV-2. It inhibits virus-induced cytotoxicity in Caco-2 cells and VERO-6 cells at a concentration of 10 µM after 48 hours, showing an inhibition of -5.9% and -0.03% respectively. Additionally, at 20 µM, Piroctone olamine inhibits the SARS-CoV-2 3CL-Pro protease by 6.202% as measured by a FRET response from a peptide substrate assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Piroctone olamine (Piroctone ethanolamine) is a compound sometimes used in the treatment of fungal infections. Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Synonyms	Piroctone ethanolamine

Chemical Properties

Molecular Weight	298.42
Formula	C₁₆H₃₀N₂O₃
Cas No.	68890-66-4
Smiles	NCCO.CC(Cc1cc(C)cc(=O)n1O)CC(C)(C)C
Relative Density.	1.1. Temperature:21.5 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 10 mg/mL (33.51 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.35 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3510 mL	16.7549 mL	33.5098 mL	167.5491 mL
5 mM	0.6702 mL	3.3510 mL	6.7020 mL	33.5098 mL
10 mM	0.3351 mL	1.6755 mL	3.3510 mL	16.7549 mL
20 mM	0.1675 mL	0.8377 mL	1.6755 mL	8.3775 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc