Gala-SR

Name: Gala-SR
Brand: TargetMol
SKU: T214377
Rating: 4.5 (1 reviews)

(Synonyms: Gala-SR1078) Copy Product Info

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Synonyms: Gala-SR1078

Catalog No. T214377 Copy Product Info

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Gala-SR is a RORα agonist that enhances the amplitude of circadian rhythms to improve rhythm disorders. It is useful for research in periodontitis.

Gala-SR

Cas No. 3092129-97-7

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Gala-SR is a RORα agonist that enhances the amplitude of circadian rhythms to improve rhythm disorders. It is useful for research in periodontitis.
In vitro	Gala-SR significantly improves compatibility with human U2OS cells via galactose modification at concentrations of 1-100 μM over 24-72 hours. At 5 μM for 24 hours, it markedly upregulates the mRNA expression of the direct target genes G6Pase and FGF21 in HepG2 cells through RORα/γ activation. Gala-SR selectively enhances RORα transcriptional activation in HEK293T cells at 5 μM. The activation effect on G6Pase and FGF21 by Gala-SR at 5 μM for 24 hours is significantly reduced upon RORα knockdown. Primarily, Gala-SR targets and activates RORα through its hydrolyzable galactose modification at 5 μM. Additionally, concentrations of 2-5 μM increase bioluminescence levels and rhythmic amplitude of BMAL1 and Per2 reporter genes, as well as elevate BMAL1 protein expression in U2OS cells.
In vivo	Gala-SR (10 mg/kg, intraperitoneally, one hour before lights-off, daily for 2 weeks) significantly enhances the amplitude of activity rhythms and total activity levels in mice. A single dose of Gala-SR (10 mg/kg, at lights-on) boosts liver luciferase signaling in PER2::LUC knock-in mice, indicating increased BMAL1 expression. Additionally, daily intraperitoneal injection of Gala-SR (10 mg/kg, for 3 weeks) restores periodontal tissue rhythm amplitude, inhibits the NF-κB inflammatory pathway, and reduces bone loss associated with periodontitis in mice.
Synonyms	Gala-SR1078

Chemical Properties

Molecular Weight	623.43
Formula	C₂₄H₂₂F₉NO₈
Cas No.	3092129-97-7
Smiles	C(OCO[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)(C(F)(F)F)(C(F)(F)F)C2=CC=C(NC(=O)C3=CC=C(C(F)(F)F)C=C3)C=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.