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Mepazine hydrochloride

Catalog No. T61153 CAS 2975-36-2

Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and influences the viability of ABC-DLBCL cells [1].

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Mepazine hydrochloride Chemical Structure

Mepazine hydrochloride, CAS 2975-36-2

Pack Size	Availability	Price/USD
5 mg	5 days	$ 39.00
10 mg	5 days	$ 56.00
1 mL * 10 mM (in DMSO)	5 days	$ 98.00

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Biological Description

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Description	Mepazine hydrochloride (Pecazine hydrochloride) is a potent and selective inhibitor of the MALT1 protease, with IC50 values of 0.83 μM for GSTMALT1 full length and 0.42 μM for GSTMALT1 325-760. It enhances apoptosis and influences the viability of ABC-DLBCL cells [1].
In vitro	Mepazine at concentrations of 5-20 μM over a period of 4 days reduces cell viability in activated B cell subtype of diffuse large B cell lymphoma (ABCDLBCL) cells, specifically HBL1, OCI-Ly3, U2932, and TMD8. This effect is observed without a significant impact on germinal center B-cell subtype of diffuse large B cell lymphoma (GCB-DLBCL) cells, including BJAB, Su-DHL-6, and Su-DHL-4, according to a Cell Viability Assay.
In vivo	Mepazine (16 mg/kg; intraperitoneal administration) significantly impedes the growth and triggers apoptosis in the ABC-DLBCL cell line OCI-Ly10 within a murine DLBCL xenogeneic tumor model in 6- to 8-week-old female NSG mice. Administering Mepazine daily at a dosage of 400 μg per animal (approximating 16 mg/kg) either starting 1 or 12 days post-transplantation and continuing every 24 hours, notably restricts the proliferation of the ABC-DLBCL cell line OCI-Ly10 [1].

Molecular Weight	346.92
Formula	C19H23ClN2S
CAS No.	2975-36-2

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Mepazine hydrochloride 2975-36-2 inhibitor inhibit

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