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Mepazine hydrochloride

Name: Mepazine hydrochloride
Brand: TargetMol
SKU: T61153
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61153Cas No. 2975-36-2

Alias Pecazine hydrochloride

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.

Mepazine hydrochloride

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Purity: 99.76%

Catalog No. T61153Alias Pecazine hydrochlorideCas No. 2975-36-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	-	In Stock
10 mg	$56	-	In Stock
25 mg	$89	-	In Stock
50 mg	$128	-	In Stock
100 mg	$187	-	In Stock
1 mL x 10 mM (in DMSO)	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.76%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.
Targets&IC50	GSTMALT1 FL:0.83 μM, GSTMALT1 325-760:0.42 μM
In vitro	Mepazine hydrochloride was most effective in inhibiting GSTMALT1 FL and GSTMALT1 325-760 with IC50 values of 0.83 and 0.42 μM. Mepazine hydrochloride had the strongest effects and MALT1 activity was reduced by at least 75% in all ABC-DLBCL cells at 10 μM. Mepazine hydrochloride and thioridazine treatment led to a significant decrease of IL-2 secretion in PBMCs. [1]
In vivo	Mepazine hydrochloride and thioridazine could also exert effects on lymphoma growth in vivo in a murine DLBCL xenogeneic tumor model. Starting 1 day after injection, the mice were treated by intraperitoneal (i.p.) administration of solvent or either Mepazine hydrochloride (16 mg/kg) or thioridazine (12 mg/kg). In control-treated mice, massive tumors grew from both DLBCL cell lines within 3 weeks of transplantation. Daily administration of Mepazine hydrochloride or thioridazine strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. Mepazine hydrochloride and thioridazine strongly reduced the progression of OCI-Ly10 tumors while having no effect on the growth of Su-DHL-6 tumors in this setting. [1]
Synonyms	Pecazine hydrochloride

Chemical Properties

Molecular Weight	346.92
Formula	C₁₉H₂₃ClN₂S
Cas No.	2975-36-2
Smiles	Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.3 mM), Sonication is recommended.

H2O: 1 mg/mL (2.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8825 mL	14.4125 mL	28.8251 mL	144.1254 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5765 mL	2.8825 mL	5.7650 mL	28.8251 mL
10 mM	0.2883 mL	1.4413 mL	2.8825 mL	14.4125 mL
20 mM	0.1441 mL	0.7206 mL	1.4413 mL	7.2063 mL
50 mM	0.0577 mL	0.2883 mL	0.5765 mL	2.8825 mL
100 mM	0.0288 mL	0.1441 mL	0.2883 mL	1.4413 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc