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Mepazine hydrochloride

Name: Mepazine hydrochloride
Brand: TargetMol
SKU: T61153
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T61153Cas No. 2975-36-2

Alias Pecazine hydrochloride

Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.

Mepazine hydrochloride

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Purity: 99.76%

Catalog No. T61153Alias Pecazine hydrochlorideCas No. 2975-36-2

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	-	In Stock
10 mg	$56	-	In Stock
25 mg	$89	-	In Stock
50 mg	$128	-	In Stock
100 mg	$187	-	In Stock
1 mL x 10 mM (in DMSO)	$40	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.76%

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Mepazine hydrochloride (Pecazine hydrochloride) is a potent MALT1 inhibitor with anticancer and antitumor activities. Mepazine hydrochloride inhibits RANK-induced osteoclastogenesis, suppresses MALT1 activity and tumor growth in pancreatic cancer.
Targets&IC50	GSTMALT1 325-760:0.42 μM, GSTMALT1 FL:0.83 μM
In vitro	Mepazine hydrochloride was most effective in inhibiting GSTMALT1 FL and GSTMALT1 325-760 with IC50 values of 0.83 and 0.42 μM. Mepazine hydrochloride had the strongest effects and MALT1 activity was reduced by at least 75% in all ABC-DLBCL cells at 10 μM. Mepazine hydrochloride and thioridazine treatment led to a significant decrease of IL-2 secretion in PBMCs. [1]
In vivo	Mepazine hydrochloride and thioridazine could also exert effects on lymphoma growth in vivo in a murine DLBCL xenogeneic tumor model. Starting 1 day after injection, the mice were treated by intraperitoneal (i.p.) administration of solvent or either Mepazine hydrochloride (16 mg/kg) or thioridazine (12 mg/kg). In control-treated mice, massive tumors grew from both DLBCL cell lines within 3 weeks of transplantation. Daily administration of Mepazine hydrochloride or thioridazine strongly impaired the expansion of the ABC-DLBCL cell line OCI-Ly10. Mepazine hydrochloride and thioridazine strongly reduced the progression of OCI-Ly10 tumors while having no effect on the growth of Su-DHL-6 tumors in this setting. [1]
Synonyms	Pecazine hydrochloride

Chemical Properties

Molecular Weight	346.92
Formula	C₁₉H₂₃ClN₂S
Cas No.	2975-36-2
Smiles	Cl.S1C=2C=CC=CC2N(C=3C=CC=CC13)CC4CN(C)CCC4

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (115.30 mM), Sonication is recommended.

H2O: 1 mg/mL (2.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8825 mL	14.4125 mL	28.8251 mL	144.1254 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5765 mL	2.8825 mL	5.7650 mL	28.8251 mL
10 mM	0.2883 mL	1.4413 mL	2.8825 mL	14.4125 mL
20 mM	0.1441 mL	0.7206 mL	1.4413 mL	7.2063 mL
50 mM	0.0577 mL	0.2883 mL	0.5765 mL	2.8825 mL
100 mM	0.0288 mL	0.1441 mL	0.2883 mL	1.4413 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc