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DHX9-IN-1

Name: DHX9-IN-1
Brand: TargetMol
SKU: T82569
Rating: 4.5 (1 reviews)

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Catalog No. T82569Cas No. 2973747-89-4

DHX9-IN-1 is an inhibitor of ATP-dependent RNA helicase DHX9, with an intracellular EC50 value of 6.94 μM. DHX9-IN-1 exhibits antitumor activity and can be used for the research of DHX9-related cancers.

DHX9-IN-1

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Catalog No. T82569Cas No. 2973747-89-4

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$228	6-8 weeks	6-8 weeks
5 mg	$587	6-8 weeks	6-8 weeks
10 mg	$868	6-8 weeks	6-8 weeks
25 mg	$1,290	6-8 weeks	6-8 weeks
50 mg	$1,730	6-8 weeks	6-8 weeks
100 mg	$2,580	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$596	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	DHX9-IN-1 is an inhibitor of ATP-dependent RNA helicase DHX9, with an intracellular EC50 value of 6.94 μM. DHX9-IN-1 exhibits antitumor activity and can be used for the research of DHX9-related cancers.
Targets&IC50	DHX9:6.94 μM (EC₅₀)

Chemical Properties

Molecular Weight	461.49
Formula	C₂₁H₂₁F₂N₅O₃S
Cas No.	2973747-89-4
Smiles	O=C(NC1=CC=CC(=C1)NS(=O)(=O)C)C=2C=C(C=3N=CC(=CC3)N4CC(F)(F)C4)N(C2)C

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (173.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1669 mL	10.8345 mL	21.6689 mL	108.3447 mL
5 mM	0.4334 mL	2.1669 mL	4.3338 mL	21.6689 mL
10 mM	0.2167 mL	1.0834 mL	2.1669 mL	10.8345 mL
20 mM	0.1083 mL	0.5417 mL	1.0834 mL	5.4172 mL
50 mM	0.0433 mL	0.2167 mL	0.4334 mL	2.1669 mL
100 mM	0.0217 mL	0.1083 mL	0.2167 mL	1.0834 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

DHX9-IN-1

DHX9-IN-1

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