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CFMTI
Catalog No. T3482 Copy Product Info
Purity: 97.88%
🥰Excellent
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.
CFMTI
Copy Product Info🥰Excellent
Catalog No. T3482
CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5.
Cas No. 864864-17-5
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | In Stock | In Stock | |
| 2 mg | $79 | In Stock | In Stock | |
| 5 mg | $129 | In Stock | In Stock | |
| 10 mg | $189 | In Stock | In Stock | |
| 25 mg | $338 | In Stock | In Stock | |
| 50 mg | $479 | In Stock | - | |
| 100 mg | $668 | Inquiry | Inquiry | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:97.88%
Appearance:Solid
Color:White
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Product Introduction
CFMTI AI Summary
CFMTI has antagonist activity at human mGluR1 and mGluR5 receptors, with IC50 values of 3.5 nM and 5400.0 nM, respectively. It shows a logD value of 1.9, reflecting its distribution coefficient. In pharmacokinetic studies, the compound demonstrates high oral bioavailability in rats at 100%, a half-life of 0.6 hours following oral (3 mg/kg) or intravenous (1 mg/kg) administration, and a plasma clearance rate of 8.1 mL.min^-1.kg^-1. Additionally, CFMTI exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease at 20 µM, with a 13.28% inhibition rate, and shows antiviral activity by reducing SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10 µM after 48 hours, with an inhibition rate of 0.04%..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | CFMTI is a potent and selective metabotropic glutamate receptor (mGluR) 1 allosteric antagonist (IC50: 2.6 nM). The selectivity of CFMTI to mGluR1 is higher 2000-fold than mGluR5. |
| Targets&IC50 | mGluR:2.6 nM, mGluR1a (rat):2.3 nM |
| Molecular Weight | 349.36 |
| Formula | C19H16FN5O |
| Cas No. | 864864-17-5 |
| Smiles | Cc1c(nnn1-c1cccnc1F)-c1ccc2C(=O)N(Cc2c1)C1CC1 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.62 mg/mL (13.22 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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