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S-trityl-L-Cysteine
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Catalog No. T36816Cas No. 2799-07-7
Alias STLC
S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5
S-trityl-L-Cysteine
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Purity: 97.02%
Catalog No. T36816Alias STLCCas No. 2799-07-7
S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $31 | In Stock | In Stock | |
| 100 mg | $44 | In Stock | In Stock | |
| 500 mg | $81 | In Stock | In Stock | |
| 1 g | $106 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.02%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | S-trityl-L-Cysteine is a potent inhibitor of human mitotic kinesin Eg5 |
| Targets&IC50 | EG5:500 nm |
| In vitro | In vitro, S-trityl-L-Cysteine targets the catalytic domain of Eg5 and inhibits Eg5 basal and microtubule-activated ATPase activity as well as mant-ADP release. S-trityl-L-Cysteine is a tight binding inhibitor (estimation of K(i,app) <150 nm at 300 mm NaCl and 600 nm at 25 mm KCl). S-trityl-L-Cysteine binds more tightly than monastrol because it has both an approximately 8-fold faster association rate and approximately 4-fold slower release rate (6.1/microM/s and 3.6/s for S-trityl-L-Cysteine versus 0.78 /microM/s and 15/s for monastrol). S-trityl-L-Cysteine inhibits Eg5-driven microtubule sliding velocity in a reversible fashion with an IC50 of 500 nm[2]. |
| Synonyms | STLC |
| Molecular Weight | 363.47 |
| Formula | C22H21NO2S |
| Cas No. | 2799-07-7 |
| Smiles | C(SC[C@@H](C(O)=O)N)(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3 |
| Relative Density. | 1.232 g/cm3 |
| Sequence | H-Cys(Trt)-OH |
| Sequence Short | X |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||
| Solubility Information | DMSO: Slightly soluble Methanol: 1 mg/mL (2.75 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Methanol
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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