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MHI-148

Name: MHI-148
Brand: TargetMol
SKU: T77553
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T77553Cas No. 172971-76-5

Alias IR-808

MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not taken up in the lysosomes and mitochondria of normal cells.MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection and diagnosis of cancer.

MHI-148

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Purity: 99.32%

Catalog No. T77553Alias IR-808Cas No. 172971-76-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 mg	$35	-	In Stock
50 mg	$60	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.32%

Appearance:Solid

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not taken up in the lysosomes and mitochondria of normal cells.MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection and diagnosis of cancer.
In vitro	Compound MHI-148 (10 µM; 1 h) demonstrates notably higher absorption in HT-29 colon carcinoma cells compared to normal NIH3T3 fibroblasts.[1] alongside its capacity for tumor imaging and targeted properties.[1] Compound MHI-148 (0-1.5 µM; 3 days) exhibits only negligible toxicity in both HT-29 and NIH3T3 cells.[1]
Cell Research	Instructions 1. Solution configuration 1. Configuration of mother liquor: Use DMSO to configure MHI-148 into 1-10mM mother liquor and store it at -20℃ or -80℃. Please aliquot it to avoid repeated freeze-thawing. 2. Configuration of working fluid: When in use, dilute the MHI-148 mother liquor into a working fluid that meets the requirements and adjust according to the experimental requirements, generally 0.4-100μM. 2. Targeted tumor imaging 1. MHI-148 is usually used in the form of a solution by injection or topical administration. 2. After injection, use a near-infrared imager to observe its accumulation in tumor cells. 3. Due to its targeting nature, MHI-148 can significantly accumulate in the lysosomes and mitochondria of cancer cells, but does not accumulate in normal cells. Therefore, tumor tissues show strong fluorescence signals. III. Application in cancer research 1. Apply MHI-148 to the cell culture system and observe its effect on tumor cells (working concentration: 0.4-100uM). 2. It can also be applied to animal models to monitor tumor growth, metastasis and other processes in real time through near-infrared imaging technology. The above information is based on published literature. Experimental procedures should be appropriately modified to meet specific research demands.
Synonyms	IR-808

Chemical Properties

Molecular Weight	764.23
Formula	C₄₂H₅₂BrClN₂O₄
Cas No.	172971-76-5
Smiles	[Br-].O=C(O)CCCCCN1C=2C=CC=CC2C(C1=CC=C3C(Cl)=C(C=CC4=[N+](C=5C=CC=CC5C4(C)C)CCCCCC(=O)O)CCC3)(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 18.7 mg/mL (24.47 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (1.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3085 mL	6.5425 mL	13.0851 mL	65.4253 mL
5 mM	0.2617 mL	1.3085 mL	2.6170 mL	13.0851 mL
10 mM	0.1309 mL	0.6543 mL	1.3085 mL	6.5425 mL
20 mM	0.0654 mL	0.3271 mL	0.6543 mL	3.2713 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MHI-148MHI148MHI 148Dye reagentCompoundMHI148