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Methyl salicylate

Name: Methyl salicylate
Brand: TargetMol
SKU: T0399
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0399Cas No. 119-36-8

Alias Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-Carbomethoxyphenol

Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.

Methyl salicylate

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Purity: 99.97%

Catalog No. T0399Alias Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-CarbomethoxyphenolCas No. 119-36-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Appearance:Liquid

Color:Transparent

Resource Download

COA LCMS GC HNMR

Product Introduction

Methyl salicylate AI Summary

Methyl salicylate inhibits the germination of Bacillus subtilis PCI219 spores with an IC50 value of 1030 μM. It demonstrates bioactivities in various assays, including: - Lamin A splicing modulation with a potency of 794.3 nM. - Agonist action on the Thyroid Stimulating Hormone Receptor, increasing intracellular cAMP concentrations in Parental HEK 293 cells with a potency of 3981.1 nM. - Small molecule agonist of the vitamin D receptor signaling pathway with a potency of 2.5 nM. - Activation of the human pregnane X receptor signaling pathway with a potency of 89.1 nM. In terms of inhibitory activities, it shows antileishmanial activity against Leishmania amazonensis and Leishmania chagasi promastigotes with IC50 values of 228.49 μM and 261.45 μM, respectively. It exhibits antifungal activity against Colletotrichum camelliae, achieving 100% mycelial growth inhibition at 2000 μg/mL and an MIC of 1770 μg/mL. The compound demonstrates insecticidal properties: - Thrips luring activity with a ratio of 4.0 for female Thrips tabaci, 13.3 for male New Zealand Thrips obscuratus, and 24.8 for female New Zealand Thrips obscuratus. - Toxicity against Musca domestica (house fly) with an LD50 of 41.2 μg and displacement of [3H]TBOB binding to the GABA receptor with 103% activity at 500 μM. - Nematicidal activity against Meloidogyne incognita with EC50 and EC100 values both >1000 μg/mL. Regarding its pharmacokinetics, Methyl salicylate has a metabolic stability half-life of 17.6 hours in 80% human plasma at pH 7.4, as determined by RP-HPLC. Methyl salicylate influences various biomarkers related to liver, kidney, and electrolyte functions, lipid metabolism, blood cell counts, inflammation, enzyme activities, and protein levels. It also shows antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells with inhibition rates of 4.31% and 0.37%, respectively, at 10 μM. Additionally, it inhibits SARS-CoV-2 3CL-Pro protease by 10.9% at 20 μM in a FRET assay. Lastly, it shows moderate inhibition in an enzymatic assay of human HDAC6 with 25.28% inhibition using a commercial peptide substrate, but demonstrates -12.93% inhibition using a custom peptide substrate..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Methyl salicylate (Gaultheria oil) is an organic ester naturally produced by many species of plants, particularly wintergreens. For acute joint and muscular pain, methyl salicylate is used as a rubefacient and analgesic in deep heating liniments.
Synonyms	Wintergreen oil, Natural wintergreen oil, Methyl 2-hydroxybenzoate, Gaultheria oil, Betula oil, 2-Carbomethoxyphenol

Chemical Properties

Molecular Weight	152.15
Formula	C₈H₈O₃
Cas No.	119-36-8
Smiles	COC(=O)C1=C(O)C=CC=C1
Relative Density.	1.174 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 25 mg/mL (164.31 mM), Sonication is recommended.

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	6.5725 mL	32.8623 mL	65.7246 mL	328.6231 mL
5 mM	1.3145 mL	6.5725 mL	13.1449 mL	65.7246 mL
10 mM	0.6572 mL	3.2862 mL	6.5725 mL	32.8623 mL
20 mM	0.3286 mL	1.6431 mL	3.2862 mL	16.4312 mL
50 mM	0.1314 mL	0.6572 mL	1.3145 mL	6.5725 mL
100 mM	0.0657 mL	0.3286 mL	0.6572 mL	3.2862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc