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TASIN-1 Hydrochloride (Alias: TASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl)

Name: TASIN-1 Hydrochloride
Brand: TargetMol
SKU: T24855
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T24855 Copy Product Info

Purity: 99.94%

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TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.

TASIN-1 Hydrochloride

Copy Product Info

😃Good

Catalog No. T24855

Alias TASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl

Cas No. 1678515-13-3

Pack Size	Price	USA Stock	Global Stock
1 mg	$71	In Stock	In Stock
5 mg	$146	In Stock	In Stock
10 mg	$207	In Stock	In Stock
25 mg	$353	In Stock	In Stock
50 mg	$503	In Stock	In Stock
100 mg	$696	In Stock	In Stock
200 mg	$938	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$153	In Stock	In Stock

In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.94%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TASIN-1 Hydrochloride (TASIN-1 HCl) is a selective inhibitor of truncated APC that acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells.
Targets&IC50	APC:70 nM(DLD1 cells)
In vivo	In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC [1].
Synonyms	TASIN-1 HCl, TASIN1 HCl, TASIN 1 HCl

Chemical Properties

Molecular Weight	388.95
Formula	C₁₈H₂₉ClN₂O₃S
Cas No.	1678515-13-3
Smiles	CC1CCN(CC1)C2CCN(CC2)S(=O)(C3=CC=C(C=C3)OC)=O.[H]Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (141.41 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5710 mL	12.8551 mL	25.7102 mL	128.5512 mL
5 mM	0.5142 mL	2.5710 mL	5.1420 mL	25.7102 mL
10 mM	0.2571 mL	1.2855 mL	2.5710 mL	12.8551 mL
20 mM	0.1286 mL	0.6428 mL	1.2855 mL	6.4276 mL
50 mM	0.0514 mL	0.2571 mL	0.5142 mL	2.5710 mL
100 mM	0.0257 mL	0.1286 mL	0.2571 mL	1.2855 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc