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VPC-70063

Name: VPC-70063
Brand: TargetMol
SKU: T60019
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60019Cas No. 13571-44-3

Alias Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.

VPC-70063

🥰Excellent

Purity: 99.98%

Catalog No. T60019Alias Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-Cas No. 13571-44-3

Pack Size	Price	Availability
1 mg	$47	In Stock
5 mg	$108	In Stock
10 mg	$163	In Stock
25 mg	$297	In Stock
50 mg	$428	In Stock
100 mg	$623	In Stock
200 mg	$878	In Stock
1 mL x 10 mM (in DMSO)	$139	In Stock

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Purity:99.98%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
In vitro	VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner[1].
Synonyms	Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

Chemical Properties

Molecular Weight	378.34
Formula	C₁₆H₁₂F₆N₂S
Cas No.	13571-44-3
Smiles	N(C(NCC1=CC=CC=C1)=S)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (118.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6431 mL	13.2156 mL	26.4313 mL	132.1563 mL
5 mM	0.5286 mL	2.6431 mL	5.2863 mL	26.4313 mL
10 mM	0.2643 mL	1.3216 mL	2.6431 mL	13.2156 mL
20 mM	0.1322 mL	0.6608 mL	1.3216 mL	6.6078 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6431 mL
100 mM	0.0264 mL	0.1322 mL	0.2643 mL	1.3216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc