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VPC-70063

Name: VPC-70063
Brand: TargetMol
SKU: T60019
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T60019Cas No. 13571-44-3

Alias Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.

VPC-70063

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Purity: 99.98%

Catalog No. T60019Alias Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-Cas No. 13571-44-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	-	In Stock
5 mg	$108	-	In Stock
10 mg	$163	-	In Stock
25 mg	$297	-	In Stock
50 mg	$428	-	In Stock
100 mg	$623	-	In Stock
200 mg	$878	-	In Stock
1 mL x 10 mM (in DMSO)	$139	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
In vitro	VPC-70063 (6.25, 12.5, and 25 μM) causes apoptosis of LNCaP cells as indicated by cleavage of PARP. VPC-70063 (0-500 μM) disrupts the interaction of Myc-Max with DNA in a dose-dependent manner[1].
Synonyms	Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-

Chemical Properties

Molecular Weight	378.34
Formula	C₁₆H₁₂F₆N₂S
Cas No.	13571-44-3
Smiles	N(C(NCC1=CC=CC=C1)=S)C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (118.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6431 mL	13.2156 mL	26.4313 mL	132.1563 mL
5 mM	0.5286 mL	2.6431 mL	5.2863 mL	26.4313 mL
10 mM	0.2643 mL	1.3216 mL	2.6431 mL	13.2156 mL
20 mM	0.1322 mL	0.6608 mL	1.3216 mL	6.6078 mL
50 mM	0.0529 mL	0.2643 mL	0.5286 mL	2.6431 mL
100 mM	0.0264 mL	0.1322 mL	0.2643 mL	1.3216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc