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FT671
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Catalog No. T12621LCas No. 1959551-26-8
Alias FT 671
FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
FT671
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Purity: 99.76%
Catalog No. T12621LAlias FT 671Cas No. 1959551-26-8
FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $58 | - | In Stock | |
| 5 mg | $133 | - | In Stock | |
| 10 mg | $223 | - | In Stock | |
| 25 mg | $488 | - | In Stock | |
| 50 mg | $846 | - | In Stock | |
| 100 mg | $1,460 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.76%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice. |
| Targets&IC50 | USP7:52 nM |
| In vitro | FT671 induces degradation of N-Myc protein and upregulation of p53 protein in the neuroblastoma cell line IMR-32. FT671 can elevate p53 protein levels in HCT116 colon carcinoma cells or the osteosarcoma (U2OS) cell line, thereby inducing the expression of p53 target genes, including BBC3 (encoding PUMA protein), CDKN1A (p21), RPS27L (S27L), and MDM2. FT671 also stabilizes p53 protein by enhancing MDM2 ubiquitination in the MM.1S multiple myeloma cell line, consequently promoting the expression of p53 target genes. |
| In vivo | FT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) demonstrated significant dose-dependent tumor growth inhibition in mice. |
| Synonyms | FT 671 |
| Molecular Weight | 533.48 |
| Formula | C24H23F4N7O3 |
| Cas No. | 1959551-26-8 |
| Smiles | O=C1C2=C(N(N=C2)C3=CC=C(F)C=C3)N=CN1CC4(O)CCN(C(C[C@@H]([C@H](F)F)N5N=C(F)C=C5)=O)CC4 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (46.86 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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