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FT671
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Catalog No. T12621LCas No. 1959551-26-8
Alias FT 671
FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
FT671
😃Good
Purity: 99.76%
Catalog No. T12621LAlias FT 671Cas No. 1959551-26-8
FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $58 | - | In Stock | |
| 5 mg | $133 | - | In Stock | |
| 10 mg | $223 | - | In Stock | |
| 25 mg | $488 | - | In Stock | |
| 50 mg | $846 | - | In Stock | |
| 100 mg | $1,460 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.76%
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Product Introduction
Bioactivity
Chemical Properties
| Description | FT671 is a non-covalent, selective USP7 inhibitor (IC50=52 nM) that binds to the catalytic domain of USP7 (Kd=7.8 µM). It disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, and inhibits tumor growth in mice. |
| Targets&IC50 | USP7:52 nM |
| In vitro | FT671 induces degradation of N-Myc protein and upregulation of p53 protein in the neuroblastoma cell line IMR-32. FT671 can elevate p53 protein levels in HCT116 colon carcinoma cells or the osteosarcoma (U2OS) cell line, thereby inducing the expression of p53 target genes, including BBC3 (encoding PUMA protein), CDKN1A (p21), RPS27L (S27L), and MDM2. FT671 also stabilizes p53 protein by enhancing MDM2 ubiquitination in the MM.1S multiple myeloma cell line, consequently promoting the expression of p53 target genes. |
| In vivo | FT671 (100 mg/kg and 200 mg/kg, oral gavage, daily) demonstrated significant dose-dependent tumor growth inhibition in mice. |
| Synonyms | FT 671 |
| Molecular Weight | 533.48 |
| Formula | C24H23F4N7O3 |
| Cas No. | 1959551-26-8 |
| Smiles | O=C1C2=C(N(N=C2)C3=CC=C(F)C=C3)N=CN1CC4(O)CCN(C(C[C@@H]([C@H](F)F)N5N=C(F)C=C5)=O)CC4 |
| Relative Density. | 1.56 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (46.86 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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