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Anti-TRIB3 Polyclonal Antibody
(Synonyms: tribbles pseudokinase 3, TRB3, SKIP3, SINK, NIPK, C20orf97) Copy Product Info
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Synonyms: tribbles pseudokinase 3, TRB3, SKIP3, SINK, NIPK, C20orf97
Catalog No. TMAB-01895 Copy Product Info
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Anti-TRIB3 Polyclonal Antibody is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P.
Anti-TRIB3 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $222 | 7-10 days | 7-10 days | |
| 100 μL | $374 | 7-10 days | 7-10 days | |
| 200 μL | $528 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-TRIB3 Polyclonal Antibody is a Rabbit antibody targeting TRIB3. Anti-TRIB3 Polyclonal Antibody can be used in FCM, IF, IHC-Fr, IHC-P. |
| Synonyms | tribbles pseudokinase 3, TRB3, SKIP3, SINK, NIPK, C20orf97 |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Chicken,Dog,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500; FCM: 1ug/test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Highest expression in liver, pancreas, peripheral blood leukocytes and bone marrow. Also highly expressed in a number of primary lung, colon and breast tumors. Expressed in spleen, thymus, and prostate and is undetectable in other examined tissues, includ |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| Immunogen | KLH conjugated synthetic peptide: human TRIB3 |
| Antigen Species | Human |
| Gene Name | TRIB3 |
| Gene ID | |
| Protein Name | Tribbles homolog 3 |
| Uniprot ID | |
| Biology Area | Diabetes associated,Cell differentiation,MAPK Pathway |
| Function | Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. |
| Molecular Weight | Theoretical: 40 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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