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TG-693

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Catalog No. T66481Cas No. 885272-55-9
Alias TG693, TG 693

TG-693 is an orally active CLK1 (CDC2-like kinase 1) inhibitor that promotes exon 31 skipping of the dystrophin gene mutation in vivo and inhibits CLK1 substrate phosphorylation, suitable for studying Duchenne muscular dystrophy (DMD).

TG-693

TG-693

😃Good
Purity: 99.81%
Catalog No. T66481Alias TG693, TG 693Cas No. 885272-55-9
TG-693 is an orally active CLK1 (CDC2-like kinase 1) inhibitor that promotes exon 31 skipping of the dystrophin gene mutation in vivo and inhibits CLK1 substrate phosphorylation, suitable for studying Duchenne muscular dystrophy (DMD).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$40-In Stock
25 mg$68-In Stock
50 mg$98-In Stock
100 mg$135-In Stock
1 mL x 10 mM (in DMSO)$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.81%
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Product Introduction

Bioactivity
Description
TG-693 is an orally active CLK1 (CDC2-like kinase 1) inhibitor that promotes exon 31 skipping of the dystrophin gene mutation in vivo and inhibits CLK1 substrate phosphorylation, suitable for studying Duchenne muscular dystrophy (DMD).
SynonymsTG693, TG 693
Chemical Properties
Molecular Weight195.23
FormulaC12H9N3
Cas No.885272-55-9
SmilesN=1C=CC(=CC1)C2=CC=C3NN=CC3=C2
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25.00 mg/mL (128.05 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM5.1222 mL25.6108 mL51.2216 mL256.1082 mL
5 mM1.0244 mL5.1222 mL10.2443 mL51.2216 mL
10 mM0.5122 mL2.5611 mL5.1222 mL25.6108 mL
20 mM0.2561 mL1.2805 mL2.5611 mL12.8054 mL
50 mM0.1024 mL0.5122 mL1.0244 mL5.1222 mL
100 mM0.0512 mL0.2561 mL0.5122 mL2.5611 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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