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Trepibutone
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Catalog No. T19764Cas No. 41826-92-0
Alias Colibil, Supacal, AA-149, AA149, AA 149
Trepibutone is an acidic drug with pH-independent release.
Trepibutone
Copy Product Info🥰Excellent
Purity: 99.95%
Catalog No. T19764Alias Colibil, Supacal, AA-149, AA149, AA 149Cas No. 41826-92-0
Trepibutone is an acidic drug with pH-independent release.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $35 | In Stock | In Stock | |
| 25 mg | $63 | In Stock | In Stock | |
| 50 mg | $95 | In Stock | In Stock | |
| 100 mg | $143 | In Stock | In Stock | |
| 200 mg | $213 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $29 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.95%
Appearance:Solid
Color:White
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Product Introduction
Trepibutone AI Summary
Trepibutone exhibits multi-faceted bioactivity as an inhibitor in various biological assays. It shows strong potency as an inhibitor of Histone Lysine Methyltransferase G9a. Additionally, it acts as a delayed death inhibitor of the malarial parasite plastid over both 48-hour and 96-hour incubations. In luciferase assays, it demonstrates potency in a Schwann cell luciferase assay and a biochemical firefly luciferase enzyme assay relevant to Niemann-Pick Disease (NPC). Furthermore, it displays activity in assays designed to identify compounds that block the entry of the Ebola Virus.
In antiviral studies, Trepibutone displays activity against SARS-CoV-2. It inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition percentage of -5.64% at 10 µM after 48 hours, as well as in VERO-6 cells, where it shows an inhibition percentage of 0.12% under similar conditions. It also inhibits the SARS-CoV-2 3CL-Pro protease by 28.89% at a concentration of 20 µM, indicating potential utility in targeting this specific viral protease.
Moreover, Trepibutone exhibits inhibitory activity on the human HDAC6 enzyme. In enzymatic assays using both commercial and custom peptide substrates, the compound demonstrated inhibition percentages of -25.88% and -6.02%, respectively, suggesting its potential as an HDAC6 inhibitor..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Trepibutone is an acidic drug with pH-independent release. |
| Synonyms | Colibil, Supacal, AA-149, AA149, AA 149 |
| Molecular Weight | 310.34 |
| Formula | C16H22O6 |
| Cas No. | 41826-92-0 |
| Smiles | CCOc1cc(OCC)c(cc1OCC)C(=O)CCC(O)=O |
| Relative Density. | 1.148 g/cm3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.11 mg/mL (10.02 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.22 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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