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Pyr3

Name: Pyr3
Brand: TargetMol
SKU: T16687
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16687Cas No. 1160514-60-2

Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

Pyr3

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Purity: 98.04%

Catalog No. T16687Cas No. 1160514-60-2

Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).

Pack Size	Price	Availability
1 mg	$30	In Stock
2 mg	$44	In Stock
5 mg	$70	In Stock
10 mg	$98	In Stock
25 mg	$226	In Stock
50 mg	$382	In Stock
100 mg	$538	In Stock
200 mg	$777	In Stock
500 mg	$1,180	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Purity:98.04%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
Targets&IC50	TRPC3:700 nM
In vitro	Pyr3 becomes apparent at 0.3 μM and is almost complete at 3 μM. Ca2+ influx is inhibited by Pyr3 in cells co-expressing TRPC3 plus TRPC6 but not in cells co-expressing TRPC1 plus TRPC5. The Ang II-induced NFAT translocation is suppressed by Pyr3 (IC50 = 0.05 μM), but weakly by Pyr2 (IC50 = 2 μM) in a concentration-dependent manner[1].

Chemical Properties

Molecular Weight	456.63
Formula	C₁₆H₁₁Cl₃F₃N₃O₃
Cas No.	1160514-60-2
Smiles	CCOC(=O)c1cnn(c1C(F)(F)F)-c1ccc(NC(=O)C(Cl)=C(Cl)Cl)cc1
Relative Density.	1.54 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (219 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1900 mL	10.9498 mL	21.8996 mL	109.4978 mL
5 mM	0.4380 mL	2.1900 mL	4.3799 mL	21.8996 mL
10 mM	0.2190 mL	1.0950 mL	2.1900 mL	10.9498 mL
20 mM	0.1095 mL	0.5475 mL	1.0950 mL	5.4749 mL
50 mM	0.0438 mL	0.2190 mL	0.4380 mL	2.1900 mL
100 mM	0.0219 mL	0.1095 mL	0.2190 mL	1.0950 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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