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Boc-NH-PEG7-NH2

Name: Boc-NH-PEG7-NH2
Brand: TargetMol
SKU: T14756
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14756Cas No. 206265-98-7

Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker.

Boc-NH-PEG7-NH2

🥰Excellent

Purity: 98.47%

Catalog No. T14756Cas No. 206265-98-7

Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker.

Pack Size	Price	Availability	Quantity
50 mg	$29	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:98.47%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description

Boc-NH-PEG7-NH2 is a PEG-based PROTAC linker.

In vitro

PROTACs, or proteolysis-targeting chimeras, are composed of two distinct ligands joined by a linker. One of these ligands binds to a specific protein target, while the other binds to an E3 ubiquitin ligase. When the PROTAC binds to both the target protein and the E3 ligase, it triggers the ubiquitin-proteasome system within cells to degrade the target protein, thereby providing a mechanism for targeted protein degradation.

Chemical Properties

Molecular Weight	468.58
Formula	C₂₁H₄₄N₂O₉
Cas No.	206265-98-7
Smiles	C(OCCOCCOCCOCCOCCOCCOCCN)CNC(OC(C)(C)C)=O
Relative Density.	1.075 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (533.53 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1341 mL	10.6705 mL	21.3411 mL	106.7054 mL
5 mM	0.4268 mL	2.1341 mL	4.2682 mL	21.3411 mL
10 mM	0.2134 mL	1.0671 mL	2.1341 mL	10.6705 mL
20 mM	0.1067 mL	0.5335 mL	1.0671 mL	5.3353 mL
50 mM	0.0427 mL	0.2134 mL	0.4268 mL	2.1341 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	1.0671 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc