IACS-9571

Name: IACS-9571
Brand: TargetMol
SKU: T11597
Rating: 4.5 (1 reviews)

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Catalog No. T11597Cas No. 1800477-30-8

Alias ASIS-P040

IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).

IACS-9571

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Catalog No. T11597Alias ASIS-P040Cas No. 1800477-30-8

IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).

Pack Size	Price	Availability
25 mg	$9,078	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Product Introduction

Bioactivity

Description	IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).
Targets&IC50	TRIM24:(kd)31 nM , TRIM24:8 nM , BRPF1:14 nM
In vitro	IACS-9571 is a selective dual TRIM24/BRPF1 inhibitor (Kd = 1.3/2.1 nM) with 9- and 21-fold selectivity against BRPF2 and BRPF3, respectively. IACS-9571 does not interact with the BET sub-family of bromodomains, displaying greater than 7,700-fold selectivity versus BRD4(1, 2) relative to TRIM24.IACS-9571 shows excellent cellular potency with EC50 of 50 nM.?IACS-9571 (1 μM) has potent activities against a panel of 32 bromodomains.
Synonyms	ASIS-P040

Chemical Properties

Molecular Weight	642.76
Formula	C₃₂H₄₂N₄O₈S
Cas No.	1800477-30-8
Relative Density.	1.246 g/cm3 (Predicted)

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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