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Anti-NR1I2 Polyclonal Antibody
(Synonyms: Steroid and xenobiotic receptor (SXR), PXR, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Nuclear receptor subfamily 1 group I member 2, NR1I2) Copy Product Info
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Synonyms: Steroid and xenobiotic receptor (SXR), PXR, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Nuclear receptor subfamily 1 group I member 2, NR1I2
Catalog No. TMAB-01265 Copy Product Info
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Anti-NR1I2 Polyclonal Antibody is a Rabbit antibody targeting NR1I2. Anti-NR1I2 Polyclonal Antibody can be used in FCM,WB.
Anti-NR1I2 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-NR1I2 Polyclonal Antibody is a Rabbit antibody targeting NR1I2. Anti-NR1I2 Polyclonal Antibody can be used in FCM,WB. |
| Synonyms | Steroid and xenobiotic receptor (SXR), PXR, Pregnane X receptor, Orphan nuclear receptor PXR, Orphan nuclear receptor PAR1, Nuclear receptor subfamily 1 group I member 2, NR1I2 |
| Ig Type | IgG |
| Reactivity | Human,Mouse (predicted:Rat,Pig,Cow,Horse) |
| Application | |
| Recommended Dose | WB: 1:500-2000; FCM: 2ug/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. |
| Tissue Specificity | Expressed in liver, colon and small intestine. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | The human nuclear pregnane X receptor (PXR) activates cytochrome P450-3A expression in response to a wide variety of xenobiotics and plays a critical role in mediating dangerous drug-drug interactions. The human PXR is related to the mouse Pxr1, which they had cloned and shown to be activated by dexamethasone, pregnenolone 16-alpha-carbonitrile (PCN), and other compounds known to induce expression of the CYP3A1 gene, the predominant form of CYP3A in rat liver and intestine. Northern blot analysis detected most abundant expression in liver, colon, and small intestine; transcripts of 2.6, 4.3, and 5 kb were present in each of these tissues. |
| Immunogen | KLH conjugated synthetic peptide: human PXR |
| Antigen Species | Human |
| Gene Name | NR1I2 |
| Gene ID | |
| Protein Name | Nuclear receptor subfamily 1 group I member 2 |
| Uniprot ID | |
| Biology Area | Orphan Nuclear Receptors,Transcription Factors,Drug metabolism,Cancer,Hormones,Drug metabolism |
| Molecular Weight | Theoretical: 48 kDa. Actual: 48 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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