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Valorphin TFA(144313-54-2(free base))

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Catalog No. T7666
Alias Valorphin TFA(144313-54-2(free bas))

Valorphin TFA(144313-54-2(free base)) is a semisynthetic derivative of dihydrovaltrate with opioid analgesic activity

Valorphin TFA(144313-54-2(free base))
Other Forms of Valorphin TFA(144313-54-2(free base)):
ValorphinT7306144313-54-2
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Valorphin TFA(144313-54-2(free base))

😃Good
Catalog No. T7666Alias Valorphin TFA(144313-54-2(free bas))
Valorphin TFA(144313-54-2(free base)) is a semisynthetic derivative of dihydrovaltrate with opioid analgesic activity
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$59In StockIn Stock
10 mg$88In StockIn Stock
25 mg$178In StockIn Stock
50 mg$272In StockIn Stock
100 mg$400In StockIn Stock
200 mg$569-In Stock
1 mL x 10 mM (in DMSO)$118In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:≥98%
Appearance:solid
Color:Yellow
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COA HNMR

Product Introduction

Bioactivity
Description
Valorphin TFA(144313-54-2(free base)) is a semisynthetic derivative of dihydrovaltrate with opioid analgesic activity
In vitro
In vitro binding studies using brain homogenates from rat and guinea-pig indicate a preference for the mu-receptor site.?Bath application to cultured cerebellar Purkinje cells inhibited the spontaneous firing, similar to the effect seen with morphine.?Analgesic activity has been demonstrated in the hot plate and the tail flick test in the mouse and the Randall-Selitto test in the rat.?In the rhesus monkey valorphin was self-administered, but naloxone challenge induced only mild withdrawal signs.?Valorphin is a novel chemical entity, structurally not related to known opioids, which interacts preferentially with opiate mu-receptors[1].
SynonymsValorphin TFA(144313-54-2(free bas))
Chemical Properties
Molecular Weight1006.03
FormulaC46H62F3N9O13
SmilesCC(C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O)C(C)C.O=C(O)C(F)(F)F
Relative Density.no data available
SequenceH-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH
Sequence ShortVVYPWTQ
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 10.07 mg/mL (10.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9940 mL4.9700 mL9.9401 mL49.7003 mL
5 mM0.1988 mL0.9940 mL1.9880 mL9.9401 mL
10 mM0.0994 mL0.4970 mL0.9940 mL4.9700 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Valorphin TFA(144313-54-2(free base))Valorphin TFA(144313542(free base))Valorphin TFA(144313 54 2(free base))
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