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CXCR3 Protein, Human, Recombinant (GST & His)

Catalog No. TMPH-01162
Synonyms: IP-10 receptor, CXCR3, CXC-R3, GPR9, Interferon-inducible protein 10 receptor, G protein-coupled receptor 9, CKR-L2, CD183, C-X-C chemokine receptor type 3, CXCR-3

CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CXCR3 Protein, Human, Recombinant (GST & His)
Pack Size Availability Price/USD Quantity
20 μg 20 days $ 284.00
100 μg 20 days $ 537.00
1 mg 20 days $ 2,300.00
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Biological Description
Technical Params
Product Properties
Description CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
Species Human
Expression System E. coli
Tag N-6xHis-GST
Accession Number P49682
Synonyms IP-10 receptor, CXCR3, CXC-R3, GPR9, Interferon-inducible protein 10 receptor, G protein-coupled receptor 9, CKR-L2, CD183, C-X-C chemokine receptor type 3, CXCR-3
Amino Acid EVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLN
Construction 4-50 aa
Protein Purity > 85% as determined by SDS-PAGE.
Molecular Weight 36.6 kDa (predicted)
Formulation Tris-based buffer, 50% glycerol
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

Research Background Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response.; Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis.; Mediates the activity of CXCL11.

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Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

CXCR3 Protein, Human, Recombinant (GST & His) IP-10 receptor CXCR3 CXC-R3 GPR9 Interferon-inducible protein 10 receptor G protein-coupled receptor 9 CKR-L2 CD183 C-X-C chemokine receptor type 3 CXCR-3 recombinant recombinant-proteins proteins protein

 

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