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Velsecorat

Name: Velsecorat
Brand: TargetMol
SKU: TQ0225
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0225Cas No. 1196509-60-0

Alias AZD7594, AZ13189620

Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).

Velsecorat

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Purity: 99.35%

Catalog No. TQ0225Alias AZD7594, AZ13189620Cas No. 1196509-60-0

Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$116	In Stock	In Stock
10 mg	$161	In Stock	In Stock
25 mg	$357	In Stock	In Stock
50 mg	$532	In Stock	In Stock
100 mg	$761	-	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.35%

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Bioactivity

Description	Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
Targets&IC50	GR:0.9 nM (IC50)
In vitro	AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).
In vivo	AZD7594 has anti-inflammatory activity and efficiently inhibits rat lung edema. AZD5423 displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation.
Synonyms	AZD7594, AZ13189620

Chemical Properties

Molecular Weight	606.62
Formula	C₃₂H₃₂F₂N₄O₆
Cas No.	1196509-60-0
Smiles	C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@@H]1CCOC1)c1ccc2OCCOc2c1
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 79 mg/mL (130.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6485 mL	8.2424 mL	16.4848 mL	82.4239 mL
5 mM	0.3297 mL	1.6485 mL	3.2970 mL	16.4848 mL
10 mM	0.1648 mL	0.8242 mL	1.6485 mL	8.2424 mL
20 mM	0.0824 mL	0.4121 mL	0.8242 mL	4.1212 mL
50 mM	0.0330 mL	0.1648 mL	0.3297 mL	1.6485 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.8242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

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