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Velsecorat

Name: Velsecorat
Brand: TargetMol
SKU: TQ0225
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0225Cas No. 1196509-60-0

Alias AZD7594, AZ13189620

Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).

Velsecorat

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Purity: 99.35%

Catalog No. TQ0225Alias AZD7594, AZ13189620Cas No. 1196509-60-0

Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
5 mg	$116	In Stock	In Stock
10 mg	$161	In Stock	In Stock
25 mg	$357	In Stock	In Stock
50 mg	$532	In Stock	In Stock
100 mg	$761	-	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.35%

Appearance:Solid

Color:White

Resource Download

COA HPLC LCMS HNMR

Product Introduction

Bioactivity

Description	Velsecorat (AZD7594) is an effective and selective nonsteroidal glucocorticoid receptor modulator (IC50: 0.9 nM).
Targets&IC50	GR:0.9 nM (IC50)
In vitro	AZD7594 shows no effect on progesterone receptor, mineralocorticoid receptor, Androgen receptor, ERα or ERβ (IC50, > 10 μM).
In vivo	AZD7594 has anti-inflammatory activity and efficiently inhibits rat lung edema. AZD5423 displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation.
Synonyms	AZD7594, AZ13189620

Chemical Properties

Molecular Weight	606.62
Formula	C₃₂H₃₂F₂N₄O₆
Cas No.	1196509-60-0
Smiles	C[C@H](NC(=O)C(C)(F)F)[C@H](Oc1ccc2n(ncc2c1)-c1cccc(c1)C(=O)N[C@@H]1CCOC1)c1ccc2OCCOc2c1
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 79 mg/mL (130.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6485 mL	8.2424 mL	16.4848 mL	82.4239 mL
5 mM	0.3297 mL	1.6485 mL	3.2970 mL	16.4848 mL
10 mM	0.1648 mL	0.8242 mL	1.6485 mL	8.2424 mL
20 mM	0.0824 mL	0.4121 mL	0.8242 mL	4.1212 mL
50 mM	0.0330 mL	0.1648 mL	0.3297 mL	1.6485 mL
100 mM	0.0165 mL	0.0824 mL	0.1648 mL	0.8242 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc