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Anti-PVRL1/NECTIN1 Antibody (3U994)
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Catalog No. TMAY-01929
Alias SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111
Anti-PVRL1/NECTIN1 Antibody (3U994) is a Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody (3U994) can be used in FCM.
Anti-PVRL1/NECTIN1 Antibody (3U994)
Anti-PVRL1/NECTIN1 Antibody (3U994)
😃Good
Catalog No. TMAY-01929Alias SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111
Anti-PVRL1/NECTIN1 Antibody (3U994) is a Mouse antibody targeting PVRL1/NECTIN1. Anti-PVRL1/NECTIN1 Antibody (3U994) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: FCM Reactivity: Human |
| Alias | SK-12, PVRR1, PVRR, PRR1, PRR, poliovirus receptor-related 1 (herpesvirus entry mediator C), OFC7, nectin-1, HVEC, HV1S, HIgR, ED4, CLPED1, CD111 |
| Ig Type | Mouse IgG2b |
| Clone | 3U994 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human PVRL1(CD111) expression on TF-1 cells. Cells were stained with purified anti-Human PVRL1(CD111), then a FITC-conjugated second step antibody. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD111 / Nectin-1 / PVRL1 (rh CD111 / Nectin-1 / PVRL1; TMPY-01572; NP_002846.3; Met1-Thr334). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin-1; CD111), also known as PVRL1 is a cell adhesion molecule belonging to the immunoglobulin superfamily that can bind to virion glycoprotein D (gD) to mediate entry of herpes simplex viruses (HSV) and pseudorabies virus (PRV). CD111/Nectin-1/PVRL1 colocalizes with E-cadherin at adherens junctions in epithelial cells. The disruption of cell junctions can result in the redistribution of nectin-1. To determine whether disruption of junctions by calcium depletion influenced the susceptibility of epithelial cells to viral entry, Madin-Darby canine kidney cells expressing endogenous nectin-1 or transfected human nectin-1 were tested for the ability to bind soluble forms of viral gD and to be infected by HSV and PRV, before and after calcium depletion. It has been revealed that binding of HSV and PRV gD was localized to adherens junctions in cells maintained in normal medium but was distributed, along with nectin-1, over the entire cell surface after calcium depletion. Both the binding of gD and the fraction of cells that could be infected by HSV-1 and PRV were enhanced by calcium depletion. Taken together, CD111/Nectin-1/PVRL1 confined to adherens junctions in epithelial cells is not very accessible to virus, whereas dissociation of cell junctions releases nectin-1 to serve more efficiently as an entry recptor. |
| Conjucates | Unconjugated |
| Others Formats | APC/PE |
| Antibody Types Available | 3 |
| Immunogen | Recombinant Protein: Human CD111 / Nectin-1 / PVRL1 protein (TMPY-01572) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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