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Monepantel

🥰Excellent
TargetMol
Catalog No. T16126Cas No. 887148-69-8
Alias PPL-1, AAD1566

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Monepantel
Other Forms of Monepantel:
(R)-MonepantelT84364887148-70-1
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Monepantel

🥰Excellent
TargetMol
Purity: 99.83%
Catalog No. T16126Alias PPL-1, AAD1566Cas No. 887148-69-8
Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$89In StockIn Stock
5 mg$263In StockIn Stock
10 mg$378In StockIn Stock
25 mg$745In StockIn Stock
50 mg$1,070In StockIn Stock
100 mg$1,530In StockIn Stock
1 mL x 10 mM (in DMSO)$288In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.83%
ee:99.77%
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Product Introduction

Bioactivity
Description
Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.
In vitro
Monepantel (0, 10, and 25 μM) induces the formation of autophagosomes in cancer cell lines, displaying a significant decrease in punctate staining levels, indicative of inhibition of phosphorylated mTOR at Ser2448[3].
In vivo
Incubating primary cultures of sheep hepatocytes with or without MOP (10μM) for 24 hours significantly enhances all CYP-related activities and CYP3A24 mRNA levels in sheep[4].
SynonymsPPL-1, AAD1566
Chemical Properties
Molecular Weight473.39
FormulaC20H13F6N3O2S
Cas No.887148-69-8
SmilesC[C@](COc1cc(ccc1C(F)(F)F)C#N)(NC(=O)c1ccc(SC(F)(F)F)cc1)C#N
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (168.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1124 mL10.5621 mL21.1242 mL105.6212 mL
5 mM0.4225 mL2.1124 mL4.2248 mL21.1242 mL
10 mM0.2112 mL1.0562 mL2.1124 mL10.5621 mL
20 mM0.1056 mL0.5281 mL1.0562 mL5.2811 mL
50 mM0.0422 mL0.2112 mL0.4225 mL2.1124 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

nAChRMonepantelAAD-1566AAD 1566
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