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Monepantel

Name: Monepantel
Brand: TargetMol
SKU: T16126
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16126Cas No. 887148-69-8

Alias PPL-1, AAD1566

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Monepantel

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Purity: 99.83%

Catalog No. T16126Alias PPL-1, AAD1566Cas No. 887148-69-8

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$378	In Stock	In Stock
25 mg	$745	In Stock	In Stock
50 mg	$1,070	In Stock	In Stock
100 mg	$1,530	-	In Stock
1 mL x 10 mM (in DMSO)	$288	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

ee:99.77%

Appearance:Solid

Color:White

Resource Download

COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.
In vitro	Monepantel (0, 10, and 25 μM) induces the formation of autophagosomes in cancer cell lines, displaying a significant decrease in punctate staining levels, indicative of inhibition of phosphorylated mTOR at Ser2448[3].
In vivo	Incubating primary cultures of sheep hepatocytes with or without MOP (10μM) for 24 hours significantly enhances all CYP-related activities and CYP3A24 mRNA levels in sheep[4].
Synonyms	PPL-1, AAD1566

Chemical Properties

Molecular Weight	473.39
Formula	C₂₀H₁₃F₆N₃O₂S
Cas No.	887148-69-8
Smiles	C[C@](COc1cc(ccc1C(F)(F)F)C#N)(NC(=O)c1ccc(SC(F)(F)F)cc1)C#N
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1124 mL	10.5621 mL	21.1242 mL	105.6212 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1242 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5621 mL
20 mM	0.1056 mL	0.5281 mL	1.0562 mL	5.2811 mL
50 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc