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Monepantel

Name: Monepantel
Brand: TargetMol
SKU: T16126
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16126Cas No. 887148-69-8

Alias PPL-1, AAD1566

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Monepantel

🥰Excellent

Purity: 99.83%

Catalog No. T16126Alias PPL-1, AAD1566Cas No. 887148-69-8

Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$89	In Stock	In Stock
5 mg	$263	In Stock	In Stock
10 mg	$378	In Stock	In Stock
25 mg	$745	In Stock	In Stock
50 mg	$1,070	In Stock	In Stock
100 mg	$1,530	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$288	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.83%

ee:99.77%

Resource Download

COA CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	Monepantel (AAD1566) is an organic anthelmintic and nicotinic acetylcholine receptor antagonist from roundworms and esophagostomies that is widely used for de-worming in agriculture and livestock.
In vitro	Monepantel (0, 10, and 25 μM) induces the formation of autophagosomes in cancer cell lines, displaying a significant decrease in punctate staining levels, indicative of inhibition of phosphorylated mTOR at Ser2448[3].
In vivo	Incubating primary cultures of sheep hepatocytes with or without MOP (10μM) for 24 hours significantly enhances all CYP-related activities and CYP3A24 mRNA levels in sheep[4].
Synonyms	PPL-1, AAD1566

Chemical Properties

Molecular Weight	473.39
Formula	C₂₀H₁₃F₆N₃O₂S
Cas No.	887148-69-8
Smiles	C[C@](COc1cc(ccc1C(F)(F)F)C#N)(NC(=O)c1ccc(SC(F)(F)F)cc1)C#N
Relative Density.	1.46 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (168.99 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (6.97 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1124 mL	10.5621 mL	21.1242 mL	105.6212 mL
5 mM	0.4225 mL	2.1124 mL	4.2248 mL	21.1242 mL
10 mM	0.2112 mL	1.0562 mL	2.1124 mL	10.5621 mL
20 mM	0.1056 mL	0.5281 mL	1.0562 mL	5.2811 mL
50 mM	0.0422 mL	0.2112 mL	0.4225 mL	2.1124 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc