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GNF362

Name: GNF362
Brand: TargetMol
SKU: T11446
Rating: 4.5 (1 reviews)

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Catalog No. T11446Cas No. 1003019-41-7

Alias GNF-362, GNF 362

GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.

GNF362

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Purity: 99.63%

Catalog No. T11446Alias GNF-362, GNF 362Cas No. 1003019-41-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$399	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Appearance:Solid

Color:White

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COA LCMS

Product Introduction

Bioactivity

Description	GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.
In vitro	GNF362 blocks Ins(1,3,4,5)P4 production, enhances antigen receptor-mediated Ca2+ responses, and leads to apoptosis of activated T cells in an Itpkb-dependent manner, while augmenting SOC responses with an EC50 value of 12 nM[1].
In vivo	In the Lewis rat antigen-induced arthritis (rAIA) model, GNF362 (6 or 20 mg/kg; oral administration; twice daily; 21 days) reduced knee joint swelling in rats by 47% in the 20 mg/kg treatment group and by 34% in the 6 mg/kg treatment group [1].
Synonyms	GNF-362, GNF 362

Chemical Properties

Molecular Weight	426.44
Formula	C₂₂H₂₁F₃N₆
Cas No.	1003019-41-7
Smiles	C[C@@H]1CN(Cc2cn[nH]c2-c2ccc(cc2)C#N)CCN1c1ccc(cn1)C(F)(F)F
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (93.8 mM), Sonication is recommended.

DMSO: 80 mg/mL (187.6 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3450 mL	11.7250 mL	23.4500 mL	117.2498 mL
5 mM	0.4690 mL	2.3450 mL	4.6900 mL	23.4500 mL
10 mM	0.2345 mL	1.1725 mL	2.3450 mL	11.7250 mL
20 mM	0.1172 mL	0.5862 mL	1.1725 mL	5.8625 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3450 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	1.1725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc