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GNF362

Name: GNF362
Brand: TargetMol
SKU: T11446
Rating: 4.5 (1 reviews)

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Catalog No. T11446Cas No. 1003019-41-7

Alias GNF-362, GNF 362

GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.

GNF362

😃Good

Purity: 99.63%

Catalog No. T11446Alias GNF-362, GNF 362Cas No. 1003019-41-7

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$399	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

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COA LCMS

Product Introduction

Bioactivity

Description	GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.
In vitro	GNF362 blocks Ins(1,3,4,5)P4 production, enhances antigen receptor-mediated Ca2+ responses, and leads to apoptosis of activated T cells in an Itpkb-dependent manner, while augmenting SOC responses with an EC50 value of 12 nM[1].
In vivo	In the Lewis rat antigen-induced arthritis (rAIA) model, GNF362 (6 or 20 mg/kg; oral administration; twice daily; 21 days) reduced knee joint swelling in rats by 47% in the 20 mg/kg treatment group and by 34% in the 6 mg/kg treatment group [1].
Synonyms	GNF-362, GNF 362

Chemical Properties

Molecular Weight	426.44
Formula	C₂₂H₂₁F₃N₆
Cas No.	1003019-41-7
Smiles	C[C@@H]1CN(Cc2cn[nH]c2-c2ccc(cc2)C#N)CCN1c1ccc(cn1)C(F)(F)F
Relative Density.	1.38 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 40 mg/mL (93.8 mM), Sonication is recommended.

DMSO: 80 mg/mL (187.60 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.74 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3450 mL	11.7250 mL	23.4500 mL	117.2498 mL
5 mM	0.4690 mL	2.3450 mL	4.6900 mL	23.4500 mL
10 mM	0.2345 mL	1.1725 mL	2.3450 mL	11.7250 mL
20 mM	0.1172 mL	0.5862 mL	1.1725 mL	5.8625 mL
50 mM	0.0469 mL	0.2345 mL	0.4690 mL	2.3450 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	1.1725 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc