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Immunology/Inflammation related

Immunology is a branch of biology and medicine that covers the study of immune systems in all organisms. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. Immunology/Inflammation related compound can target related diseases.

Tamarixetin
TN1039603-61-2
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy.
  • $83
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Carotuximab
T769411268714-50-6
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.
  • $247
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Galiximab
T76809357613-77-5
Galiximab (IDEC 114) is a primate-type anti-CD80 immunoglobulin G1 (IgG1)-like monoclonal antibody with antitumor activity that induces in vivo growth inhibition and prolongs survival of B-NHL tumor xenografts. Galiximab has been used in the study of hematologic malignancies.
  • $247
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Ac-YVAD-CMK
T36347178603-78-6
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
  • $64
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Pirazolac
T1248471002-09-0In house
Pirazolac (ZK-76604) is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
  • $1,520
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1,3,6-Tri-O-galloyl-beta-D-glucose
TN116618483-17-5
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
  • $118
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INCB3619
T27603791826-72-7In house
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
  • $195
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Antalarmin hydrochloride
T22577220953-69-5
Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.
  • $58
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Omburtamab
T782741895083-75-6
Omburtamab is a monoclonal antibody targeting CD276, often conjugated to 131 radioactive iodine ions, used for radioimmuno positron emission tomography studies.
  • $213
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Meranzin
TN101523971-42-8
Meranzin, a bioactive compound derived from the Traditional Chinese Medicine (TCM) Chaihu-Shugan-San (CSS) and isolated from Murraya exotica L. leaves, targets the alpha 2-adrenoceptor and engages the AMPA-ERK1 2–BDNF signaling pathway. It offers promising potential for preventing the comorbidity of atherosclerosis and depression due to its significant anti-inflammatory and analgesic properties.
  • $106
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GI254023X
T7522260264-93-5
GI254023X is a MMP9 and ADAM10 inhibitor with IC50 values ​​of 2.5 and 5.3 nM, respectively. GI254023X can also significantly inhibit the proliferation of Jurkat cells and induce apoptosis.
  • $97
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Arnidiol
TN11116750-30-7
Arnidiol, a pentacyclic triterpene isolated from Barleria Longiflora Linn, exhibits anti-inflammatory activity, notably inhibiting 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
  • $122
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Fendosal
T1996753597-27-6
Fendosal (HP-129) is a non-steroidal anti-inflammatory agent. It is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation.
  • $117
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JG26
T276541464910-32-4In house
JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.
  • $83
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3-Epiursolic acid
TN1249989-30-0
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the
  • $48
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Tormentic acid
TN111813850-16-3
Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
  • $68
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Dehydropachymic acid
TN156377012-31-8
(S)-Leucic acid is an amino acid metabolite used as a muscle builder.
  • $113
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Dehydrotumulosic acid
TN10856754-16-1
Dehydrotumulosic acid shows anti-inflammatory activity.
  • $68
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ZLDI-8
T13410667880-38-8
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
  • $52
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beta-Escin
T884611072-93-8
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
  • $50
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TIM-3-IN-2
T793651113126-49-0
TIM-3-IN-2 is a Tim3 inhibitor that inhibits the binding of TIM-3 to PtdSer, CEACAM1, and Gal-9 and inhibits the action of TIM-3.TIM-3-IN-2 is able to reverse TIM-3-mediated pro-inflammatory cytokine action.
  • $149
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Glucosyringic acid
TN169733228-65-8
Glucosyringic acid has immunosuppressive effect, it can inhibit the proliferation of murine B lymphocytes in vitro.
  • $210
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Heraclenin
TL00132880-49-1
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels
  • $68
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Acanthoside B
TN13557374-79-0
Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation.
  • $68
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Thymulin
TP232463958-90-7
Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune-modulatory and anti-inflammatory effects
  • $45
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Kaempferol 3-O-β-D-galactopyranoside
TN182323627-87-4
Kaempferol 3-O-β-D-galactopyranoside possesses antioxidant, anti-inflammatory, and antinociceptive activities.
  • $128
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Myricetin 3-O-glucoside
TN196119833-12-6
Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) is a flavonol extracted from Tibouchina paratropica, exhibiting anti-leishmania, anti-inflammatory, and antibacterial activities.
  • $118
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8-Epideoxyloganic acid
T383488668-99-9
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit
  • $83
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Fenclozic acid
T861417969-20-9
[2-(4-Chlorophenyl)-1,3-thiazol-4-yl]acetic acid (2-[2-(4-CHLOROPHENYL)-1,3-THIAZOL-4-YL]ACETIC ACID) is an anti-inflammatory thiazole
  • $50
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Adenosine N1-oxide
T23636146-92-9
Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.
  • $61
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Anti-inflammatory agent 35
T643582293951-00-3
Anti-inflammatory agent 35 is a potent anti-inflammatory agent.
  • $38
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Chlorthenoxazine
T14955132-89-8
Chlorthenoxazine (Chlorethylbenzmethoxazone) has anti-inflammatory activity.
  • $37
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Anti-inflammatory agent 36
T643592293951-01-4
Anti-inflammatory agent 36 is an anti-inflammatory agent that exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages (IC50 = 3.69 μM and 3.68 μM, respectively).
  • $43
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Seselin
TN5891523-59-1
Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.
  • $122
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Lintuzumab
T9901A-065166089-32-3
Lintuzumab (HuM-195) is a non-coupled humanized mouse monoclonal antibody directed against the cell-surface myelomonocyte differentiation antigen, CD33, with anti-leukemic activity that reduces the production of TNFα-induced pro-inflammatory cytokines and chemokines by AML cells.Lintuzumab has antitumor activity and induces cell death directly via CDC or ADCC. Lintuzumab has anti-tumor activity and induces cell death directly via CDC or ADCC.
  • $195
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Coltuximab
T9901A-013
Coltuximab is a humanized anti-CD19 antibody that can be used to synthesize ADC compounds (Coltuximab Ravtansine).
  • $445
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ABTIM3-hum11
T9901A-014
ABTIM3-hum11 is a humanized anti-TIM3 blood-brain barrier shuttling monoclonal antibody.
  • $195
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Ataquimas
T9840586348-21-2In house
Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.
  • $33
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Anti-MRC2/CD280 Antibody
T9901A-076
Anti-MRC2 CD280 Antibody is a humanized anti-MRC2 CD280 antibody that can be used in immunoblotting (WB) and immunohistochemistry experiments.
  • $445
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Izeltabart Tapatansine
T9901A-084
Izeltabart Tapatansine (IMGC-936) is a CHO-expressing humanized next-generation medetonin-based ADC compound targeting ADAM9-expressing tumors, and exhibits cytotoxicity against ADAM9-positive human tumor cell lines for cancer research.
  • $450
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Ibritumomab
T9901A-012
Ibritumomab is a murine-derived anti-CD20 monoclonal antibody that kills tumor cells by forming free radicals in target cells and surrounding tissues.Ibritumomab is used in the study of non-Hodgkin's lymphoma.
  • $195
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ABTIM3-hum03
T9901A-015
ABTIM3-hum03 is a humanized anti-TIM3 blood-brain barrier shuttling monoclonal antibody.
  • $195
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Glimepiride sulfonamide
T64332119018-29-0
Glimepiride sulfonamide is an antiinflammatory agent.
  • $31
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Anti-inflammatory agent 34
T9748867301-81-3
Anti-inflammatory agent 34 shows moderate acute anti-inflammatory activity and analgesic activity in vivo.
  • $34
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Bucolome
T10632841-73-6
Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.
  • $70
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Letolizumab
T770611450981-87-9
Letolizumab (BMS-986004) is a dimeric antibody targeting CD40L for the expression of mutant IgG1 that lacks effector functions including Fc binding and complement binding.1 Letolizumab does not induce platelet activation in vitro and does not affect coagulation factors or platelet counts function after repeated dosing in non-human primates.
  • $169
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TL4-12
T262801620820-12-3
TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM).
  • $106
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Cudarolimab
T771532244739-29-3
Cudarolimab (IBI-101) is a fully human anti-OX40 antibody with potential immune checkpoint inhibitory and anti-tumor activity for the study of cancer.
  • $289
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