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Immunology/Inflammation related

Both the inflammatory response and the immune response are the body's defense mechanisms against various internal and external stimuli. The inflammatory response is often part of the immune response, which is usually acute and non-specific, whereas the immune response can be specific and may last longer after the infection has cleared. The inflammatory response functions primarily through local effects, while the immune response involves systemic regulation.

Galiximab
T76809357613-77-5
Galiximab (IDEC 114) is a primate-type anti-CD80 immunoglobulin G1 (IgG1)-like monoclonal antibody with antitumor activity that induces in vivo growth inhibition and prolongs survival of B-NHL tumor xenografts. Galiximab has been used in the study of hematologic malignancies.
  • $247
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Tamarixetin
TN1039603-61-2
Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy.
  • $83
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TargetMol | Citations Cited
Glycyrrhisoflavone
TN1705116709-70-7
Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
  • $119
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Carotuximab
T769411268714-50-6
Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.
  • $129
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Dehydropachymic acid
TN156377012-31-8
(S)-Leucic acid is an amino acid metabolite used as a muscle builder.
  • $113
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N-trans-caffeoyltyramine
TN6457103188-48-3
N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.
  • $97
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Ac-YVAD-CMK
T36347178603-78-6
Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
  • $64
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Dehydrotumulosic acid
TN10856754-16-1
Dehydrotumulosic acid shows anti-inflammatory activity.
  • $68
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GI254023X
T7522260264-93-5
GI254023X is a MMP9 and ADAM10 inhibitor with IC50 values ​​of 2.5 and 5.3 nM, respectively. GI254023X can also significantly inhibit the proliferation of Jurkat cells and induce apoptosis.
  • $97
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1,3,6-Tri-O-galloyl-beta-D-glucose
TN116618483-17-5
1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.
  • $118
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Pirazolac
T1248471002-09-0In house
Pirazolac (ZK-76604) is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.
  • $293
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Tafasitamab
T771351422527-84-1
Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
  • $428
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(+)-Isolariciresinol
TN1782548-29-8
(+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis, exhibits antioxidant and anti-inflammatory activities, and is applicable in rheumatism studies.
  • $129
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INCB3619
T27603791826-72-7In house
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
  • $183
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Sericoside
T12466355306-04-2
Sericoside, a triterpenoid compound, is obtained from Terminalia and exhibits potent anti-inflammatory properties. Additionally, sericoside displays robust lipolytic activity, thereby aiding in the reduction of skin wrinkles and improvement of skin texture.
  • $58
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Schisantherin E
T3S192564917-83-5
Schisantherin E is a natural lignan isolated from Schisandra chinensis. Schisandra chinensis has antioxidant, hepatoprotective, sedative, anticancer, anti-SARS and anti-inflammatory activities.
  • $213
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Tormentic acid
TN111813850-16-3
Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
  • $68
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beta-Escin
T884611072-93-8
beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
  • $50
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Omburtamab
T782741895083-75-6
Omburtamab is a monoclonal antibody targeting CD276, often conjugated to 131 radioactive iodine ions, used for radioimmuno positron emission tomography studies.
  • $213
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Ganoderic acid C2
TN1661103773-62-2
Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.
  • $55
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Caulophyllogenin
TN147552936-64-8
Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the prevention and treatment of inflammatory diseases, type-2 diabetes, obesity and metabolic syndrome.
  • $113
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JG26
T276541464910-32-4In house
JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.
  • $83
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Bryodulcosigenin
TN14554965-97-3
Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.
  • $68
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Antalarmin hydrochloride
T22577220953-69-5
Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.
  • $32
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