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Immunology/Inflammation related

Immunology is a branch of biology and medicine that covers the study of immune systems in all organisms. Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants, and is a protective response involving immune cells, blood vessels, and molecular mediators. Immunology/Inflammation related compound can target related diseases.

  • (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one
    T67757240131-71-9
    (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one is a major mechanism of Sinomenine. Sinomenine is an alkaloid derived from the Chinese herb Sinomenium acutum (Thunb.) Rehd. et Wils. (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one exhibits anti-inflammation effects.
    • $195
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  • Fendosal
    T1996753597-27-6
    Fendosal (HP-129) is a non-steroidal anti-inflammatory agent. It is 6.9 to 9.5 times more active than aspirin in the prophylactic and therapeutic adjuvant-induced polyarthritis models of chronic inflammation.
    • $195
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  • 11-O-Galloylbergenin
    T383282958-44-9
    11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.
    • $193
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  • Adenosine N1-oxide
    T23636146-92-9
    Adenosine N1-oxide (1-Oxoadenosine), which is found in royal jelly, inhibited the secretion of inflammatory mediators by activated macrophages and reduced lethality in lipopolysaccharide (LPS)-induced endotoxin shock.
    • $61
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  • Bryodulcosigenin
    TN14554965-97-3
    Bryodulcosigenin has anti-inflammatory effect, it shows potent inhibitory effects on EBV-EA induction.
    • $133
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  • Homobutein
    TN422034000-39-0
    Homobutein (3-O-Methylbutein) is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.
    • $195
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  • Chlorthenoxazine
    T14955132-89-8
    Chlorthenoxazine (Chlorethylbenzmethoxazone) has anti-inflammatory activity.
    • $61
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  • INCB3619
    T27603791826-72-7In house
    INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15.
    • $195
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  • Ataquimas
    T9840586348-21-2In house
    Ataquimast inhibits IL-5 secretion along with that of TNF-a, IL-4 and GM-CSF from human cells.
    • $55
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  • JG26
    T276541464910-32-4In house
    JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body.
    • $102
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  • Tamarixetin
    TN1039603-61-2
    Tamarixetin (4'-O-Methyl Quercetin) (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin, with anti-inflammatory and anti-oxidative effects. Tamarixetin protects against cardiac hypertrophy.
    • $83
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    TargetMol | Citations Cited
  • Talacotuzumab
    T768831826831-79-1
    Talacotuzumab (JNJ 56022473) is an IgG1 fully humanized CD123 neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has a high affinity for CD123, CD32b/c, CD16-158F and CD16-158V, with KD of 0.43 nM, 188 nM, 46 nM and 16.8 nM, respectively. Talacotuzumab inhibits IL-3 signaling in target cells by inhibiting IL-3 binding to CD123. Talacotuzumab induces mutations in the Fc region to increase affinity for CD16 (FCγriiia), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab inhibits leukemia cell growth in xenografted mouse models of acute myeloid leukemia (AML).
    • $497
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  • Telazorlimab
    T773692126777-87-3
    Telazorlimab (GBR-830) is a humanized monoclonal antibody that targets the OX40 co-stimulatory receptor on activated T cells. Telazorlimab can be used to treat lupus erythematosus and atopic dermatitis.
    • $247
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  • Carotuximab
    T769411268714-50-6
    Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.
    • $247
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  • TL4-12
    T262801620820-12-3
    TL4-12 is a specific MAP4K2/GCK inhibitor that inhibits IKZF1 and BCL-6.TL4-12 inhibits MM cell proliferation and induces apoptosis, and can be used in the study of multiple myeloma (MM).
    • $106
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  • Djalonensone
    TN340323452-05-3
    Djalonensone (Alternariol monomethyl ether), an Alternaria toxin, is a strong mutagen in Escherichia coli strain ND-160. Alternariol monomethyl ether has genotoxic properties, it can cause oxidative DNA damage. It also possesses cytotoxic and immunosuppressive properties.
    • $280
    35 days
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  • Dehydrotumulosic acid
    TN10856754-16-1
    Dehydrotumulosic acid shows anti-inflammatory activity.
    • $108
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  • 8-Epideoxyloganic acid
    T383488668-99-9
    8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during oxidative stress, the inhibition of ROS production, possibly through modulation of NOX activit
    • $83
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  • Anti-inflammatory agent 34
    T9748867301-81-3
    Anti-inflammatory agent 34 shows moderate acute anti-inflammatory activity and analgesic activity in vivo.
    • $56
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  • Seselin
    TN5891523-59-1
    Seselin is a natural product from Plumbago zeylanica. Seselin shows anti-inflammatory and antiviral activity.
    • $122
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  • Chaetoglobosin Fex
    TN6716149457-95-4
    Chaetoglobosin Fex from the marine-derived endophytic fungus inhibits induction of inflammatory mediators via Toll-like receptor 4 signaling in macrophages.
    • $645
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  • Tafasitamab
    T771351422527-84-1
    Tafasitamab (XmAb5574) is an FC-modified humanized monoclonal antibody targeting the human B-cell surface antigen CD19 for the study of diffuse large B-cell lymphoma.
    • $428
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  • Anti-inflammatory agent 35
    T643582293951-00-3
    Anti-inflammatory agent 35 is a potent anti-inflammatory agent.
    • $38
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  • Anti-inflammatory agent 36
    T643592293951-01-4
    Anti-inflammatory agent 36 is an anti-inflammatory agent. It exhibited dose-dependent inhibition of LPS-induced release of TNF-a and IL-6 in active RAW 264.7 mouse macrophages, IC50=3.69uM and 3.68uM, respectively.
    • $43
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  • Vorsetuzumab
    T773621165740-62-4
    Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a monoclonal antibody targeting the CD70 antibody. Vorsetuzumab has anticancer activity and can enhance the macrophage-associated phagocytosis of kidney cancer cells and inhibit Burkitt lymphoma.
    • $247
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  • Ac-YVAD-CMK
    T36347178603-78-6
    Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.
    • $64
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  • Arjungenin
    TN140258880-25-4
    Arjungenin, a triterpene derived from Terminalia arjuna, exhibits insect feeding-deterrent and growth inhibitory properties.
    • $79
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  • Sericoside
    T12466355306-04-2
    Sericoside, a triterpenoid compound, is obtained from Terminalia and exhibits potent anti-inflammatory properties. Additionally, sericoside displays robust lipolytic activity, thereby aiding in the reduction of skin wrinkles and improvement of skin texture.
    • $58
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  • Heraclenin
    TL00132880-49-1
    Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels
    • $68
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  • Arnidiol
    TN11116750-30-7
    Arnidiol has anti-inflammatory activity, it possesses marked inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice.
    • $122
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  • GI254023X
    T7522260264-93-5
    GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis of H929 cells. Its mechanism may be associated with inbihition of Notch1 activation.
    • $97
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  • Eburicoic acid
    TN1599560-66-7
    Eburicoic acid (ZINC4655149) exhibits anti-inflammatory and antioxidant activity thereby protecting the liver from CCl4-induced hepatic damage and can be used in studies about anti-liver cancer.
    • $76
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  • Glimepiride sulfonamide
    T64332119018-29-0
    Glimepiride sulfonamide is an antiinflammatory agent.
    • $39
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  • Taiwanin C
    TN628414944-34-4
    Taiwanin C is a compound extracted from the Taiwan plant Cryptocarya chinensis, which belongs to the lignan class of compounds and has many biological activities such as anti-inflammatory, antioxidant and anticancer. The Taiwanin C can inhibit the production of inflammatory mediators and oxidative stress in cells.
    • $1,850
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  • Caulophyllogenin
    TN147552936-64-8
    Caulophyllogenin is a partial PPARγ agonist (EC50 = 12.6 μM) derived from the stem bark of Kalopanax pictus (Araliaceae). Caulophyllogenin inhibits pro-inflammatory cytokine secretion and can be used in studies about the prevention and treatment of inflammatory diseases, type-2 diabetes, obesity and metabolic syndrome.
    • $113
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  • Bucolome
    T10632841-73-6
    Bucolome (Paramidine) is a CYP2C9 inhibitor with uricosuric and anti-inflammatory activity.
    • $117
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  • (+)-Isolariciresinol
    TN1782548-29-8
    (+)-Isolariciresinol ((+)-Cyclolariciresinol) is extracted from Radix Isatidis and shows antioxidant and anti-inflammatory activities and can be used in studies about rheumatism.
    • $129
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  • Dehydropachymic acid
    TN156377012-31-8
    (S)-Leucic acid is an amino acid metabolite used as a muscle builder.
    • $113
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  • Benzyl cinnamate
    T8145103-41-3
    Benzyl cinnamate (Benzylcinnamoate) is a natural product isolated from various plant species,with anti-inflammatory activity.
    • $42
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  • Glycyrrhisoflavone
    TN1705116709-70-7
    Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.
    • $119
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  • Antalarmin hydrochloride
    T22577220953-69-5
    Antalarmin hydrochloride is an antagonist of corticotropin-releasing factor 1(CRF1). Antalarmin hydrochloride produces anti-inflammatory effects and suppresses stress-induced gastric ulceration related to irritable bowel syndrome.
    • $58
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  • Myricetin 3-O-glucoside
    TN196119833-12-6
    Myricetin 3-O-glucoside (Myricetin 3-O-beta-D-glucopyranoside) is a flavonol extracted from Tibouchina paratropica. Myricetin 3-O-glucoside has many activities, including anti-leishmania, anti-inflammatory and antibacterial activities.
    • $118
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  • Omburtamab
    T782741895083-75-6
    Omburtamab is a monoclonal antibody targeting CD276, often conjugated to 131 radioactive iodine ions, used for radioimmuno positron emission tomography studies.
    • $258
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  • beta-Escin
    T884611072-93-8
    beta-Escin is a natural mixture of triterpenoid saponins isolated from horse chestnut (Aesculus hippocastanum) seeds, can be used as a vasoprotective anti-inflammatory, anti-edematous and anti-nociceptive agent.
    • $50
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  • Ganoderic acid C2
    TN1661103773-62-2
    Ganoderic acid C2 has anti-inflammatory,and anti-tumor-promoting activities. Ganoderic acid C2 can inhibit histamine release, it also has inhibitory effects on the induction of Epstein-Barr Virus early antigen.
    • $55
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  • Thymulin
    TP232463958-90-7
    Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune-modulatory and anti-inflammatory effects
    • $45
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  • Tormentic acid
    TN111813850-16-3
    Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties,
    • $68
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  • Handelin
    TN113162687-22-3
    Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
    • $64
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  • N-trans-caffeoyltyramine
    TN6457103188-48-3
    N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.
    • $97
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  • 3-O-Acetyl-16α-hydroxytrametenolic acid
    TN1256168293-13-8
    3-O-Acetyl-16α-hydroxytrametenolic acid has inhibitory activities against AAPH-induced hemolysis of red blood cells, it shows a strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice.
    • $129
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