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Immunology/Inflammation

Aryl Hydrocarbon Receptor

Immunology/Inflammation related

NOD-like Receptor (NLR)

Prostaglandin Receptor

Reactive Oxygen Species

Thrombopoietin Receptor

Immunology/Inflammation related

Both the inflammatory response and the immune response are the body's defense mechanisms against various internal and external stimuli. The inflammatory response is often part of the immune response, which is usually acute and non-specific, whereas the immune response can be specific and may last longer after the infection has cleared. The inflammatory response functions primarily through local effects, while the immune response involves systemic regulation.

Filter HomeSignaling PathwaysImmunology/InflammationImmunology/Inflammation related

Rituximab

T9910174722-31-7

Rituximab is an anti-CD20 chimeric monoclonal antibody used to study certain autoimmune diseases and cancers.

$229

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Galiximab

T76809357613-77-5

Galiximab (IDEC 114) is a primate-type anti-CD80 immunoglobulin G1 (IgG1)-like monoclonal antibody with antitumor activity that induces in vivo growth inhibition and prolongs survival of B-NHL tumor xenografts. Galiximab has been used in the study of hematologic malignancies.

$247

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Tamarixetin

TN1039603-61-2

Tamarixetin (4'-O-Methyl Quercetin) is a natural flavonoid derivative of quercetin that exhibits anti-inflammatory and antioxidative effects, offering protection against cardiac hypertrophy.

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Carotuximab

T769411268714-50-6

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.

$129

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N-trans-caffeoyltyramine

TN6457103188-48-3

N-trans-caffeoyltyramine (Trans-N-Caffeoyltyramine) is a modulator of inflammatory responses and can be used in studies about treatment for chronic inflammatory diseases.

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Inebilizumab

T767131299440-37-1

Inebilizumab is a humanized anti-CD19 monoclonal antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used to treat a range of autoimmune diseases associated with CD19 B cells, such as multiple sclerosis and optic neuromyelitis.

$157

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Glycyrrhisoflavone

TN1705116709-70-7

Glycyrrhisoflavone is a tyrosinase inhibitor with anti-inflammatory effects. Glycyrrhisoflavone inhibits α-glucosidase and monoamine oxidase.

$119

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(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one

T67757240131-71-9

(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one is a major mechanism of Sinomenine. Sinomenine is an alkaloid derived from the Chinese herb Sinomenium acutum (Thunb.) Rehd. et Wils. (9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-7,8-didehydromorphinan-6-one exhibits anti-inflammation effects.

$126

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Dehydropachymic acid

TN156377012-31-8

(S)-Leucic acid is an amino acid metabolite used as a muscle builder.

$107

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MG-T-19

T201721328540-44-9

MG-T-19, a TIM-3 inhibitor (KD=0.26 μM), significantly inhibited the interaction of TIM-3 with PtdSer, CEACAM1, and Gal-9, and increased the production of TNF-α and IFN-γ in PBMCs, which reactivated the tumor-attacking ability of T cells.

$195

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Mosunetuzumab

T766921905409-39-3

Mosunetuzumab (BCT-4465A) is a humanized antibody based on immunoglobulin G1 that targets CD20 (B cells) and CD3 (T cells). Mosunetuzumab redirects T cells to engage and eliminate malignant B cells and can be used to study relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL) and refractory follicular lymphoma.

$228

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Ipilimumab

T9906477202-00-9

Ipilimumab (anti-CTLA-4) is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor.

$456

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Anti-Mouse CD8α Antibody (2.43)

T9901A-146

Anti-Mouse CD8α Antibody (2.43) is a mouse-derived IgG2b kappa antibody targeting CD8α in mice, with an isotype control of Rat IgG2b kappa, Isotype Control, and can be used for flow cytometry analysis.

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BR102910

T98552505339-54-6

BR102910 (4-Thiazolecarboxamide, N-[2-[(2S)-2-cyano-4,4-difluoro-1-pyrrolidinyl]-2-oxoethyl]-2-[(3,4-dichlorophenyl)methyl]-) is a selective inhibitor of fibroblast activated protein (FAP).

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Ac-YVAD-CMK

T36347178603-78-6

Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity.

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Dehydrotumulosic acid

TN10856754-16-1

Dehydrotumulosic acid shows anti-inflammatory activity.

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GI254023X

T7522260264-93-5

GI254023X is a MMP9 and ADAM10 inhibitor with IC50 values of 2.5 and 5.3 nM, respectively. GI254023X can also significantly inhibit the proliferation of Jurkat cells and induce apoptosis.

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Theralizumab

T77093906068-56-2

Theralizumab (TGN1412) is an anti-CD28-targeting monoclonal antibody that directly stimulates T cells. Theralizumab has antitumor activity and is used for the treatment of B-cell chronic lymphocytic leukemia and rheumatoid arthritis.

$745

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1,3,6-Tri-O-galloyl-beta-D-glucose

TN116618483-17-5

1,3,6-Tri-O-galloyl-beta-D-glucose (1,3,6-Tri-O-galloylglucose) is a phenolic compound found in Black Walnut Kernels, exhibiting anti-inflammatory activity.

$118

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Tremelimumab

T77466745013-59-6

Tremelimumab is a cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) blocking antibody.Tremelimumab is often used in combination with Durvalumab for the treatment of solid cancers such as hepatocellular carcinoma and lung cancer.

$155

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Glofitamab

T766852229047-91-8

Glofitamab (RO7082859) is a novel bivalent antibody directed against CD20-binding T cells.Glofitamab promotes T cell proliferation and activation and tumor cell killing by binding to CD20 on malignant cells.Glofitamab can be used for the palliation of relapsed or refractory B-cell lymphomas.

$478

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Pirazolac

T1248471002-09-0In house

Pirazolac (ZK-76604) is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.

$293

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Sibrotuzumab

T76792216669-97-5

Sibrotuzumab (BIBH 1) is a humanized IgG1 monoclonal antibody targeting Fibroblast Activating Protein (FAP) and is used in the study of colorectal cancer and non-small cell lung cancer.