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Anti-C-Kit Antibody (3F840)
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Catalog No. TMAY-02196
Alias v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117
Anti-C-Kit Antibody (3F840) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (3F840) can be used in ELISA,IHC-P.
Anti-C-Kit Antibody (3F840)
Anti-C-Kit Antibody (3F840)
😃Good
Catalog No. TMAY-02196Alias v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117
Anti-C-Kit Antibody (3F840) is a Rabbit antibody targeting C-Kit. Anti-C-Kit Antibody (3F840) can be used in ELISA,IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
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Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA, IHC-P Reactivity: Human |
| Alias | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, SCFR, PBT, C-Kit, CD117 |
| Ig Type | Rabbit IgG |
| Clone | 3F840 |
| Reactivity | Human |
| Verified Activity | 1. Immunochemical staining of human c-KIT in human skin with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human c-KIT in human melanoma with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human c-KIT in human breast cancer with rabbit monoclonal antibody (1:300, formalin-fixed paraffin embedded sections). |
| Application | ELISA,IHC-P |
| Recommended Dose | ELISA: 1:5000-1:10000; IHC-P: 1:100-1:500 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human c-Kit / CD117 (rh c-Kit / CD117; TMPY-01935; P10721-2; Met1-Thr516). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human c-Kit / CD117 protein (TMPY-01935) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets, Cardiac Stem Cell Markers, Receptor Tyrosine Kinases (RTKs) |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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