TPP1 Protein, Human, Recombinant (His)

Name: TPP1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-02767
Price: 75 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: tripeptidyl peptidase I, TPP-1, SCAR7, LPIC, GIG1, CLN2) Copy Product Info

Synonyms: tripeptidyl peptidase I, TPP-1, SCAR7, LPIC, GIG1, CLN2

Catalog No. TMPY-02767 Copy Product Info

Purity: 96%

TPP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.7 kDa and the accession number is AAH14863.1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$75	-	In Stock
10 µg	$118	-	In Stock
20 µg	$196	-	In Stock
50 µg	$386	-	In Stock
100 µg	$660	7-10 days	7-10 days
200 µg	$1,120	7-10 days	7-10 days
500 µg	$2,270	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:96%

Appearance:Solution

Color:Transparent

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by the cleavage of AlaAlaPheAMC. The specific activity is > 850 pmoles/min/μg.
Description	TPP1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 60.7 kDa and the accession number is AAH14863.1.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	C-His
Accession Number	AAH14863.1
Construction	A DNA sequence encoding the pro form of human TPP1 (AAH14863.1) (Met 1-Pro 563) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ser 20
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% gly.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	tripeptidyl peptidase I, TPP-1, SCAR7, LPIC, GIG1, CLN2
Research Background	Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. TPP1 / CLN2 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Defects in TPP1 / CLN2 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2), a form of neuronal ceroid lipofuscinosis which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.

Chemical Properties

Molecular Weight

60.7 kDa (predicted); 60 kDa (reducing conditions)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.