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BMS986187
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Catalog No. T8991Cas No. 684238-37-7
BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.
BMS986187
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Purity: 99.09%
Catalog No. T8991Cas No. 684238-37-7
BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $33 | In Stock | In Stock | |
| 2 mg | $47 | In Stock | In Stock | |
| 5 mg | $76 | In Stock | In Stock | |
| 10 mg | $122 | In Stock | In Stock | |
| 25 mg | $239 | In Stock | In Stock | |
| 50 mg | $347 | In Stock | In Stock | |
| 100 mg | $538 | In Stock | In Stock | |
| 500 mg | $1,150 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.09%
Appearance:Solid
Color:White
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Product Introduction
BMS986187 AI Summary
BMS986187 acts as a positive allosteric modulator of the human delta opioid receptor-1 (DOR), enhancing the responses to various ligands such as leu-enkephalin, SNC80, and TAN67. It potentiates the intrinsic efficacy and binding affinity of these ligands and modulates the activity of ERK1/2 phosphorylation and cAMP accumulation pathways. Additionally, BMS986187 exhibits agonist activity at the delta opioid receptor-1 and shows selectivity towards the mu opioid receptor. Notably, it demonstrates bioactivity related to the inhibition of DOR expressed in CHO cells, reducing phosphorylated ERK1/2 levels and inhibiting Leu-enkephalin-induced ERK1/2 phosphorylation and cAMP levels, as measured by EC50 and Emax values in various assays. These results suggest that BMS986187 has significant pharmacological effects on the DOR signaling pathway..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor. |
| Molecular Weight | 470.6 |
| Formula | C31H34O4 |
| Cas No. | 684238-37-7 |
| Smiles | Cc1ccccc1COc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)OC2=C1C(=O)CC(C)(C)C2 |
| Relative Density. | no data available |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.72 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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