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Befovacimab
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Catalog No. T76921Cas No. 2156634-62-5
Alias BAY 1093884
Befovacimab (BAY 1093884) is a fully human monoclonal antibody directed against tissue factor pathway inhibitor (TFPI). By blocking the inhibitory activity of TFPI on Factor Xa and the tissue factor-Factor VIIa (TF-VIIa) complex, it restores thrombin generation, holding significant potential for the treatment research of Hemophilia A and B.
Befovacimab
Befovacimab
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Catalog No. T76921Alias BAY 1093884Cas No. 2156634-62-5
Befovacimab (BAY 1093884) is a fully human monoclonal antibody directed against tissue factor pathway inhibitor (TFPI). By blocking the inhibitory activity of TFPI on Factor Xa and the tissue factor-Factor VIIa (TF-VIIa) complex, it restores thrombin generation, holding significant potential for the treatment research of Hemophilia A and B.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Related Conjugates and Formulations
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Chemical Properties
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Storage & Solubility Information
| Description | Befovacimab (BAY 1093884) is a fully human monoclonal antibody directed against tissue factor pathway inhibitor (TFPI). By blocking the inhibitory activity of TFPI on Factor Xa and the tissue factor-Factor VIIa (TF-VIIa) complex, it restores thrombin generation, holding significant potential for the treatment research of Hemophilia A and B. |
| Targets&IC50 | TFPI:4.65 nM |
| In vitro | Befovacimab binds with high affinity (<10 pM) to the K1 and K2 domains of human TFPI, inhibiting its interaction with Factor Xa (FXa) and FVIIa, thereby successfully restoring their biological activities [2]. |
| In vivo | In female cynomolgus monkeys, IV or SC administration of Befovacimab (5 and 20 mg/kg) dose-dependently reduces systemic TFPI levels and shortens clotting time. In monkey plasma, the IC50 values for inhibiting free TFPI and shortening diluted prothrombin time (dPT) are 4.65 nM and 6.19 nM, respectively [2]. |
| Synonyms | BAY 1093884 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | TFPI |
| Cas No. | 2156634-62-5 |
| Isotype | IgG2SA |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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