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AZ 5704
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Catalog No. T35942Cas No. 1941214-06-7
Alias AZ-5704, AZ5704, ATM Inhibitor-10
AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan in the SW620 xenograft model.
AZ 5704
😃Good
Purity: 99.69%
Catalog No. T35942Alias AZ-5704, AZ5704, ATM Inhibitor-10Cas No. 1941214-06-7
AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan in the SW620 xenograft model.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $109 | - | In Stock | |
| 5 mg | $267 | - | In Stock | |
| 10 mg | $393 | - | In Stock | |
| 25 mg | $676 | - | In Stock | |
| 50 mg | $952 | - | In Stock | |
| 100 mg | $1,280 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.69%
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AZ 5704 (compound 74) is a selective and orally active ATM inhibitor (IC50 = 0.6 nM), which can enhance the anti-tumor activity of irinotecan in the SW620 xenograft model. |
| Targets&IC50 | DNAPK:370 nM, ATM:0.6 nM, PI3Kα:0.445 μM, mTOR:1.48 μM |
| In vivo | Method: In immunodeficient SW620 (colorectal cell line) tumor-bearing mice, administer Irinotecan (50 mg/kg, intraperitoneal injection, once daily on Day 1) and AZ 5704 (50 mg/kg, oral, twice daily on Days 2 and 4; no dosing on Days 5 and 7). Results: AZ 5704 monotherapy showed no significant efficacy. However, after 3 weeks of combination therapy with Irinotecan, tumor growth in the SW620 xenograft model was markedly reduced, with greater efficacy than Irinotecan monotherapy. |
| Synonyms | AZ-5704, AZ5704, ATM Inhibitor-10 |
| Molecular Weight | 434.47 |
| Formula | C23H23FN6O2 |
| Cas No. | 1941214-06-7 |
| Smiles | N([C@@H](C)C1=NN(C)C=C1)C=2C3=C(C=C(F)C(=C3)C=4C=CC(COC)=NC4)N=CC2C(N)=O |
| Relative Density. | 1.36 g/cm3 (Predicted) |
| Color | White |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: Soluble, Sonication is recommended. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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