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LOX-IN-3 dihydrochloride monohydrate

Catalog No. T61479 CAS 2414974-55-1

LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].

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LOX-IN-3 dihydrochloride monohydrate Chemical Structure

LOX-IN-3 dihydrochloride monohydrate, CAS 2414974-55-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 2,140.00
50 mg	6-8 weeks	$ 2,785.00
100 mg	6-8 weeks	$ 3,520.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].
In vitro	LOX-IN-3 dihydrochloride monohydrate (Compound 33) effectively inhibits bovine LOX and human LOXL2, demonstrating IC 50 values of <10 μM and <1 μM, respectively [1]. This compound maintains prolonged inhibition of LOXL1 and LOXL2, while exhibiting reduced activity against SSAO/VAP-1 and MAO-B [1].
In vivo	LOX-IN-3 dihydrochloride monohydrate (Compound 33), administered at different dosages and durations, has been shown to influence fibrosis and enzyme activity in various animal models. At a dosage of 30 mg/kg administered orally once, it completely abolished lysyl oxidase activity in male Wistar rats, with plasma concentrations of the compound dropping below the IC 50 after 8 hours, and recovery half-life ranging from 2-3 days (ear) to 24 hours (aorta) [1]. When given orally daily at 10 mg/kg for 14 days to mice in a unilateral ureteric obstruction (UUO) model, it resulted in increased kidney weight and thickness while reducing fibrosis area [1]. Moreover, a daily oral dose of 15 mg/kg for 21 days significantly decreased lung fibrosis in C57Bl/6 mice, as shown by reductions in both the Ashcroft score and lung weight [1].

Molecular Weight	371.25
Formula	C13H17Cl2FN2O3S
CAS No.	2414974-55-1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LOX-IN-3 dihydrochloride monohydrate 2414974-55-1 inhibitor inhibit

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