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Anti-Mcl-1 Antibody (4I237)
😃Good
Catalog No. TMAY-00215
Alias TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3
Anti-Mcl-1 Antibody (4I237) is a Mouse antibody targeting Mcl-1. Anti-Mcl-1 Antibody (4I237) can be used in IHC-P.
Anti-Mcl-1 Antibody (4I237)
Anti-Mcl-1 Antibody (4I237)
😃Good
Catalog No. TMAY-00215Alias TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3
Anti-Mcl-1 Antibody (4I237) is a Mouse antibody targeting Mcl-1. Anti-Mcl-1 Antibody (4I237) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $198 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-Mcl-1 Antibody (4I237) is a Mouse antibody targeting Mcl-1. Anti-Mcl-1 Antibody (4I237) can be used in IHC-P. |
| Alias | TM, MCL1S, MCL1L, MCL1-ES, mcl1/EAT, Mcl-1, EAT, bcl2-L-3, BCL2L3 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 4I237 |
| Reactivity | Human |
| Verified Activity | Immunochemical staining of human MCL1 in human breast carcinoma with mouse monoclonal antibody (1:30, formalin-fixed paraffin embedded sections). |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:20-1:80 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human Mcl-1. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | MCL1 is an anti-apoptotic protein in the BCL2 family and amplifies frequently in multiple human cancers. Myeloid cell leukemia sequence 1 (MCL1) is a potent anti-apoptotic protein that plays a critical role in cell survival and drug resistance in various cancers. MCL1 is a pivotal member of the anti-apoptotic BCL-2 family proteins. While a distinctive feature of MCL1 resides in its efficient ubiquitination and destruction, the deubiquitinase USP9X has been implicated in the preservation of MCL1 expression by removing the polyubiquitin chains.MCL1 is also known as a potential contributor to the resistance of BCL2 inhibitors, as well as various chemotherapeutic drugs. MCL1 is, therefore, regarded as a potential target for cancer therapy. The overexpression of MCL1 promotes cell survival and confers chemotherapeutic resistance. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide corresponding to the center region of the Human Mcl-1 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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