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Carisbamate

Name: Carisbamate
Brand: TargetMol
SKU: T30748
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30748Cas No. 194085-75-1

Alias RWJ-333369, RWJ333369, RWJ 333369, JNJ-10234094, JNJ10234094

Carisbamate (RWJ-333369) is an orally active neuromodulator that suppresses the development and propagation of epileptiform discharges, confers neuroprotection following epilepticus-like injury in vitro, and demonstrates robust antiepileptic efficacy in genetic models of generalized and nonconvulsive epilepsy, supporting its translational relevance in epilepsy research.

Carisbamate

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Purity: 99.94%

Catalog No. T30748Alias RWJ-333369, RWJ333369, RWJ 333369, JNJ-10234094, JNJ10234094Cas No. 194085-75-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$30	-	In Stock
5 mg	$68	-	In Stock
10 mg	$112	-	In Stock
25 mg	$226	-	In Stock
50 mg	$339	-	In Stock
100 mg	$513	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Carisbamate (RWJ-333369) is an orally active neuromodulator that suppresses the development and propagation of epileptiform discharges, confers neuroprotection following epilepticus-like injury in vitro, and demonstrates robust antiepileptic efficacy in genetic models of generalized and nonconvulsive epilepsy, supporting its translational relevance in epilepsy research.
In vitro	In cultured hippocampal neurons, Carisbamate (200 μM) acutely inhibited spontaneous recurrent epileptiform discharges (SREDs) after 12 hours in over 95% of neurons, with effects maintained for 24 hours [1].
In vivo	In the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) model, intraperitoneal (i.p.) administration of Carisbamate (10, 30, 60 mg/kg) reduced the expression of spike-and-wave discharges (SWD) dose-dependently. The 60 mg/kg dose completely inhibited SWD after 120 minutes. In audiogenic sensitive Wistar AS rats, Carisbamate (20, 30 mg/kg, i.p.) prevented wild running episodes and tonic seizures in all animals. At 10 mg/kg, the latency to tonic seizure was increased by 327% [6].
Synonyms	RWJ-333369, RWJ333369, RWJ 333369, JNJ-10234094, JNJ10234094

Chemical Properties

Molecular Weight	215.63
Formula	C₉H₁₀ClNO₃
Cas No.	194085-75-1
Smiles	[C@H](COC(N)=O)(O)C1=C(Cl)C=CC=C1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (371.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6376 mL	23.1879 mL	46.3757 mL	231.8787 mL
5 mM	0.9275 mL	4.6376 mL	9.2751 mL	46.3757 mL
10 mM	0.4638 mL	2.3188 mL	4.6376 mL	23.1879 mL
20 mM	0.2319 mL	1.1594 mL	2.3188 mL	11.5939 mL
50 mM	0.0928 mL	0.4638 mL	0.9275 mL	4.6376 mL
100 mM	0.0464 mL	0.2319 mL	0.4638 mL	2.3188 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc