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Anti-WNK1 Antibody (1O394)
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Catalog No. TMAH-01252
Alias WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1
Anti-WNK1 Antibody (1O394) is an antibody targeting WNK1. Anti-WNK1 Antibody (1O394) can be used in ELISA, IHC.
Anti-WNK1 Antibody (1O394)
Anti-WNK1 Antibody (1O394)
😃Good
Catalog No. TMAH-01252Alias WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1
Anti-WNK1 Antibody (1O394) is an antibody targeting WNK1. Anti-WNK1 Antibody (1O394) can be used in ELISA, IHC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $207 | 7-10 days | |
| 100 μL | $349 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Recombinant Rabbit Monoclonal Application: ELISA, IHC Reactivity: Human |
| Alias | WNK 1, Serine/threonine-protein kinase WNK1, Protein kinase with no lysine 1, Protein kinase lysine-deficient 1, PRKWNK1, p65, Kinase deficient protein, KIAA0344, KDP, hWNK1, HSN2, Erythrocyte 65 kDa protein, EC 2.7.11.1 |
| Ig Type | Rabbit IgG |
| Clone | 1O394 |
| Reactivity | Human |
| Verified Activity | 1. IHC image of TMAH-01252 diluted at 1:50 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.60% DAB. 2. IHC image of TMAH-01252 diluted at 1:50 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.60% DAB. |
| Application | ELISA, IHC |
| Recommended Dose | IHC:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cytoplasm. |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D and SGK1. Controls sodium and chloride ion transport by inhibiting the activity of WNK4, by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4, SLC26A6 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition. Dominant-negative regulator of the longer isoform 1. Does not have kinase activity, does not directly inhibit WNK4 and has no direct effect on sodium and chloride ion transport. Downregulates sodium-chloride cotransporter activity indirectly by inhibiting isoform 1, it associates with isoform 1 and attenuates its kinase activity. In kidney, may play an important role regulating sodium and potassium balance. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human WNK1 |
| Antigen Species | Human |
| Gene ID | 65125 |
| Uniprot ID | |
| Biology Area | Signal transduction |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
Sci Citations
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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