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LY83583
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Catalog No. T21576Cas No. 91300-60-6
Alias 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
LY83583
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Purity: 99.80%
Catalog No. T21576Alias 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedioneCas No. 91300-60-6
LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $55 | In Stock | In Stock | |
| 10 mg | $89 | In Stock | In Stock | |
| 25 mg | $178 | In Stock | In Stock | |
| 50 mg | $289 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.80%
Appearance:Solid
Color:Red
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Product Introduction
LY83583 AI Summary
LY83583 exhibits a broad spectrum of inhibitory and regulatory activities across different biological systems. In the context of vascular biology, it shows inhibitory activity in the vasorelaxation process induced by acetylcholine on phenylephrine-precontracted rat aorta with intact endothelium, featuring an EC50 value of 335.0 nM and achieving 77.0% of maximal acetylcholine-induced vasorelaxation. In yeast assays, LY83583 inhibits the cytostatic effect of 50 nM rapamycin in Saccharomyces cerevisiae strain BY4742 with an EC50 value of 10400.0 nM and affects the expression of a variety of genes, indicating its regulatory roles in gene expression. Specifically, it increases the expressions of GUF1, FMP38, HMI1, YRR1, YDR514C, SUV3, PET111, MDL1, MRPS28, and MAM1, while decreasing the expressions of FET4, RIM11, HOS1, YDR222W, YKR75C, YJL051W, SGN1, and YMD8. Additionally, LY83583 inhibits yeast Guf1 with an IC50 value of 300000.0 nM. It also exhibits potency in a range of assays, including inhibition of Tyrosyl-DNA Phosphodiesterase (TDP1), Tau Fibril Formation, ROR gamma transcriptional activity, Aldehyde Dehydrogenase, Bacillus subtilis Sfp phosphopantetheinyl transferase, IMPase, Histone Lysine Methyltransferase G9a, and the Menin-MLL Interaction. Furthermore, it shows activity against Glioma stress response, vitamin D receptor inhibition, and viral binding or entry inhibition for Lassa Virus, Marburg Virus, and Foot and Mouth Disease Virus. Notably, LY83583 also inhibits soluble guanylate cyclase with an IC50 value of 1000.0 nM. These diverse activities suggest that LY83583 has potential therapeutic implications across various biological pathways and disease models..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LY83583 is a soluble guanylate cyclase competitive inhibitor with IC50 of 2 µM. |
| Synonyms | 6-anilinoquinoline-5,8-dione, 6-Anilino-5,8-quinolinedione |
| Molecular Weight | 250.25 |
| Formula | C15H10N2O2 |
| Cas No. | 91300-60-6 |
| Smiles | O=C1C=C(Nc2ccccc2)C(=O)c2cccnc12 |
| Relative Density. | 1.400 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 2.51 mg/mL (10.03 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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