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Trimethoprim

Name: Trimethoprim
Brand: TargetMol
SKU: T1153
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1153Cas No. 738-70-5

Alias NSC-106568, NIH 204, BW 56-72

Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.

Trimethoprim

🥰Excellent

Purity: 99.81%

Catalog No. T1153Alias NSC-106568, NIH 204, BW 56-72Cas No. 738-70-5

Pack Size	Price	Availability	Quantity
500 mg	$45	In Stock

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Purity:99.81%

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Product Introduction

Bioactivity

Description	Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.
In vivo	Trimethoprim acts by interfering with the bacterial dihydrofolate reductase, inhibiting the synthesis of tetrahydrofolic acid. This inhibition causes a deficiency in nucleotides essential for bacterial DNA replication, which in some instances leads to cell death due to thymineless death.
Synonyms	NSC-106568, NIH 204, BW 56-72

Chemical Properties

Molecular Weight	290.32
Formula	C₁₄H₁₈N₄O₃
Cas No.	738-70-5
Smiles	COC1=CC(CC2=CN=C(N)N=C2N)=CC(OC)=C1OC
Relative Density.	1.1648 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 122 mg/mL (420.23 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4445 mL	17.2224 mL	34.4448 mL	172.2238 mL
5 mM	0.6889 mL	3.4445 mL	6.8890 mL	34.4448 mL
10 mM	0.3444 mL	1.7222 mL	3.4445 mL	17.2224 mL
20 mM	0.1722 mL	0.8611 mL	1.7222 mL	8.6112 mL
50 mM	0.0689 mL	0.3444 mL	0.6889 mL	3.4445 mL
100 mM	0.0344 mL	0.1722 mL	0.3444 mL	1.7222 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc