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CPS-11
🥰Excellent
Catalog No. T23911Cas No. 145945-21-7
Alias N-(Hydroxymethyl)thalidomide, CPS11, CPS 11
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
CPS-11
🥰Excellent
Purity: 98.55%
Catalog No. T23911Alias N-(Hydroxymethyl)thalidomide, CPS11, CPS 11Cas No. 145945-21-7
CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $397 | In Stock | |
| 5 mg | $892 | In Stock | |
| 10 mg | $1,180 | In Stock | |
| 25 mg | $1,580 | In Stock | |
| 50 mg | $1,980 | In Stock | |
| 100 mg | $2,500 | In Stock |
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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Purity:98.55%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line. |
| In vitro | Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1]. Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2]. At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2]. Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2]. |
| Synonyms | N-(Hydroxymethyl)thalidomide, CPS11, CPS 11 |
| Molecular Weight | 288.26 |
| Formula | C14H12N2O5 |
| Cas No. | 145945-21-7 |
| Smiles | O=C1N(C(=O)C=2C1=CC=CC2)C3C(=O)N(CO)C(=O)CC3 |
| Relative Density. | 1.555 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (156.11 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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