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CPS-11

Name: CPS-11
Brand: TargetMol
SKU: T23911
Price: 238 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T23911Cas No. 145945-21-7

Alias N-(Hydroxymethyl)thalidomide, CPS11, CPS 11

CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.

CPS-11

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Purity: 99.98%

Catalog No. T23911Alias N-(Hydroxymethyl)thalidomide, CPS11, CPS 11Cas No. 145945-21-7

CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$238	In Stock	In Stock
5 mg	$535	In Stock	In Stock
10 mg	$708	In Stock	In Stock
25 mg	$948	In Stock	In Stock
50 mg	$1,180	In Stock	In Stock
100 mg	$1,500	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	CPS-11 (N-(Hydroxymethyl)thalidomide) is a Thalidomide analogue with significant antitumor activity, exhibiting a broader and more potent effect on the MM (multiple myeloma) cell line.
In vitro	Confirming its ability to target tumor cells in the bone marrow microenvironment, CPS-11 abrogates the ability of bone marrow stromal cells (BMSCs) to induce proliferation of MM cells[1]. Showing virtually no effect on the activation of p38 and only slight, transient activation of ATF2 and HSP27 (0-200 μM, 0 or 4 h), CPS-11 demonstrates its pharmacological behavior[2]. At doses as high as 100 μM, CPS-11 (0-100 μM, 24 or 48 h) exhibits no toxicity to H157 cells, WT MEFs, or the p38α-/- MEFs[2]. Furthermore, CPS-11 (50 μM, 24 or 48 h) does not induce apoptosis in H157 cells[2].
Synonyms	N-(Hydroxymethyl)thalidomide, CPS11, CPS 11

Chemical Properties

Molecular Weight	288.26
Formula	C₁₄H₁₂N₂O₅
Cas No.	145945-21-7
Smiles	O=C1N(C(=O)C=2C1=CC=CC2)C3C(=O)N(CO)C(=O)CC3
Relative Density.	1.555 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (156.11 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4691 mL	17.3455 mL	34.6909 mL	173.4545 mL
5 mM	0.6938 mL	3.4691 mL	6.9382 mL	34.6909 mL
10 mM	0.3469 mL	1.7345 mL	3.4691 mL	17.3455 mL
20 mM	0.1735 mL	0.8673 mL	1.7345 mL	8.6727 mL
50 mM	0.0694 mL	0.3469 mL	0.6938 mL	3.4691 mL
100 mM	0.0347 mL	0.1735 mL	0.3469 mL	1.7345 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc