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BAY-784

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Catalog No. T10475Cas No. 1631164-24-3
Alias BAY-784, BAY784, BAY 784

BAY-784 is a potent gonadotropin-releasing hormone receptor (GnRH-R) antagonist that exhibits strong inhibitory activity with IC50 values of 21 nM for human GnRH-R and 24 nM for rat GnRH-R, BAY-784 is widely applied in endocrine research to study GnRH signaling, reproductive hormone regulation, and therapeutic modulation of hormone-dependent physiological and pathological processes.

BAY-784

BAY-784

😃Good
Purity: 99.75%
Catalog No. T10475Alias BAY-784, BAY784, BAY 784Cas No. 1631164-24-3
BAY-784 is a potent gonadotropin-releasing hormone receptor (GnRH-R) antagonist that exhibits strong inhibitory activity with IC50 values of 21 nM for human GnRH-R and 24 nM for rat GnRH-R, BAY-784 is widely applied in endocrine research to study GnRH signaling, reproductive hormone regulation, and therapeutic modulation of hormone-dependent physiological and pathological processes.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$92-In Stock
5 mg$225-In Stock
10 mg$335-In Stock
25 mg$558-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
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Batch Information

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Purity:99.75%
ee:100%
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Product Introduction

Bioactivity
Description
BAY-784 is a potent gonadotropin-releasing hormone receptor (GnRH-R) antagonist that exhibits strong inhibitory activity with IC50 values of 21 nM for human GnRH-R and 24 nM for rat GnRH-R, BAY-784 is widely applied in endocrine research to study GnRH signaling, reproductive hormone regulation, and therapeutic modulation of hormone-dependent physiological and pathological processes.
Targets&IC50
GnRHR:21 nM
In vivo
Method: BAY-784 was administered orally at 0.5, 3, 10, or 30 mg/kg as a single dose in ovariectomized rats.
Result: BAY-784 reduced plasma luteinizing hormone levels in a dose-dependent manner[1].
SynonymsBAY-784, BAY784, BAY 784
Chemical Properties
Molecular Weight672.11
FormulaC29H26ClF4N3O5S2
Cas No.1631164-24-3
SmilesS(=O)(=O)(N1[C@H](C2(C=3C1=CC=C(C(NCC4=C(Cl)C=C(C(F)(F)F)C=N4)=O)C3)CCS(=O)(=O)CC2)C5CC5)C6=CC=C(F)C=C6
Relative Density.1.60 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 32 mg/mL (47.61 mM), Sonication and heating are recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.4879 mL7.4393 mL14.8785 mL74.3926 mL
5 mM0.2976 mL1.4879 mL2.9757 mL14.8785 mL
10 mM0.1488 mL0.7439 mL1.4879 mL7.4393 mL
20 mM0.0744 mL0.3720 mL0.7439 mL3.7196 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
The above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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