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FT001
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Catalog No. T27392Cas No. 1778655-51-8
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects against MV-4-11 and demonstrates significant MYC mRNA suppression both in vitro and in vivo.
FT001
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Purity: 99.9%
Catalog No. T27392Cas No. 1778655-51-8
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects against MV-4-11 and demonstrates significant MYC mRNA suppression both in vitro and in vivo.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $117 | In Stock | In Stock | |
| 2 mg | $175 | In Stock | In Stock | |
| 5 mg | $268 | In Stock | In Stock | |
| 10 mg | $394 | In Stock | In Stock | |
| 25 mg | $592 | In Stock | In Stock | |
| 50 mg | $828 | In Stock | In Stock | |
| 100 mg | $1,130 | - | In Stock | |
| 500 mg | $2,260 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $315 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:99.9%
ee:100%
Appearance:Solid
Color:White
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Product Introduction
FT001 AI Summary
FT001 exhibits robust bioactivities, including the inhibition of His-epitope tagged BRD4 bromodomain 1 with an IC50 of 100.0 nM. It shows significant growth inhibition of human MV411 cells, with a GI50 value of 220.0 nM, and inhibits BRD4 in these cells with an IC50 of 460.0 nM, which leads to a reduction in MYC mRNA expression. In stability assays, 95.0% of the parent compound remains intact after 30 minutes in mouse liver microsomes, and it has a plasma half-life of over 0.4 hours in mice. The compound's MTD in orally dosed athymic Hsd:Foxn1nu mice is 12.5 mg/kg. At this dosage, it also demonstrates the ability to reduce MYC mRNA levels in tumors xenografted with human MV411 cells, achieving a fold change of 0.2. Additionally, FT001 achieves complete tumor growth inhibition (TGI) at 100.0% when administered at 12.5 mg/kg twice daily for 20 days in athymic Hsd:Foxn1nu mice xenografted with human MV411 cells..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects against MV-4-11 and demonstrates significant MYC mRNA suppression both in vitro and in vivo. |
| Molecular Weight | 467.58 |
| Formula | C25H29N3O4S |
| Cas No. | 1778655-51-8 |
| Smiles | C(=O)(N1C=2C(N(C(C)=O)[C@@H](C)C1)=CC=C(C2)C3=CC=C(C=C3)N4CCS(=O)(=O)CC4)C5CC5 |
| Relative Density. | 1.319 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (96.24 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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